Aspergillus niger as a Secondary Metabolite Factory

Aspergillus niger as a Secondary Metabolite Factory

Aspergillus niger, one of the most common and important fungal species, is ubiquitous in various environments. A. niger isolates possess a large number of cryptic biosynthetic gene clusters (BGCs) and produce various biomolecules as secondary metabolites with a broad spectrum of application fields c...

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Bibliographic Details
Main Authors: Ronglu Yu, Jia Liu, Yi Wang, Hong Wang, Huawei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Chemistry
Subjects:
Aspergillus niger
secondary metabolite
bioactivity
biosynthesis
application
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.701022/full
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spelling doaj-a357604fc06a4c8bbeeaf3ff4e3040a72021-07-30T08:52:44ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-07-01910.3389/fchem.2021.701022701022Aspergillus niger as a Secondary Metabolite FactoryRonglu Yu0Jia Liu1Yi Wang2Hong Wang3Hong Wang4Huawei Zhang5Huawei Zhang6School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, ChinaSchool of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, ChinaSchool of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, ChinaSchool of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, ChinaKey Laboratory of Marine Fishery Resources Exploitment and Utilization of Zhejiang Province, Hangzhou, ChinaSchool of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, ChinaKey Laboratory of Marine Fishery Resources Exploitment and Utilization of Zhejiang Province, Hangzhou, ChinaAspergillus niger, one of the most common and important fungal species, is ubiquitous in various environments. A. niger isolates possess a large number of cryptic biosynthetic gene clusters (BGCs) and produce various biomolecules as secondary metabolites with a broad spectrum of application fields covering agriculture, food, and pharmaceutical industry. By extensive literature search, this review with a comprehensive summary on biological and chemical aspects of A. niger strains including their sources, BGCs, and secondary metabolites as well as biological properties and biosynthetic pathways is presented. Future perspectives on the discovery of more A. niger-derived functional biomolecules are also provided in this review.https://www.frontiersin.org/articles/10.3389/fchem.2021.701022/fullAspergillus nigersecondary metabolitebioactivitybiosynthesisapplication
collection DOAJ
language English
format Article
sources DOAJ
author Ronglu Yu
Jia Liu
Yi Wang
Hong Wang
Hong Wang
Huawei Zhang
Huawei Zhang
spellingShingle Ronglu Yu
Jia Liu
Yi Wang
Hong Wang
Hong Wang
Huawei Zhang
Huawei Zhang
Aspergillus niger as a Secondary Metabolite Factory
Frontiers in Chemistry
Aspergillus niger
secondary metabolite
bioactivity
biosynthesis
application
author_facet Ronglu Yu
Jia Liu
Yi Wang
Hong Wang
Hong Wang
Huawei Zhang
Huawei Zhang
author_sort Ronglu Yu
title Aspergillus niger as a Secondary Metabolite Factory
title_short Aspergillus niger as a Secondary Metabolite Factory
title_full Aspergillus niger as a Secondary Metabolite Factory
title_fullStr Aspergillus niger as a Secondary Metabolite Factory
title_full_unstemmed Aspergillus niger as a Secondary Metabolite Factory
title_sort aspergillus niger as a secondary metabolite factory
publisher Frontiers Media S.A.
series Frontiers in Chemistry
issn 2296-2646
publishDate 2021-07-01
description Aspergillus niger, one of the most common and important fungal species, is ubiquitous in various environments. A. niger isolates possess a large number of cryptic biosynthetic gene clusters (BGCs) and produce various biomolecules as secondary metabolites with a broad spectrum of application fields covering agriculture, food, and pharmaceutical industry. By extensive literature search, this review with a comprehensive summary on biological and chemical aspects of A. niger strains including their sources, BGCs, and secondary metabolites as well as biological properties and biosynthetic pathways is presented. Future perspectives on the discovery of more A. niger-derived functional biomolecules are also provided in this review.
topic Aspergillus niger
secondary metabolite
bioactivity
biosynthesis
application
url https://www.frontiersin.org/articles/10.3389/fchem.2021.701022/full
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