Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer

Xiaoding Hu et al. find that expression of the proteoglycan decorin is decreased in patients with inflammatory breast cancer compared to normal breast tissue and some other types of breast cancer. They demonstrate that decorin acts as a tumor suppressor in cancer cells and human xenograft mouse mode...

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Main Authors:	Xiaoding Hu, Emilly S. Villodre, Richard Larson, Omar M. Rahal, Xiaoping Wang, Yun Gong, Juhee Song, Savitri Krishnamurthy, Naoto T. Ueno, Debu Tripathy, Wendy A. Woodward, Bisrat G. Debeb
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-01-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-020-01590-0

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spelling	doaj-a35e725f4a31444ab59fa8714d1e455f2021-01-17T12:27:09ZengNature Publishing GroupCommunications Biology2399-36422021-01-014111410.1038/s42003-020-01590-0Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancerXiaoding Hu0Emilly S. Villodre1Richard Larson2Omar M. Rahal3Xiaoping Wang4Yun Gong5Juhee Song6Savitri Krishnamurthy7Naoto T. Ueno8Debu Tripathy9Wendy A. Woodward10Bisrat G. Debeb11Department of Breast Medical Oncology, the University of Texas MD Anderson Cancer CenterDepartment of Breast Medical Oncology, the University of Texas MD Anderson Cancer CenterMorgan Welch Inflammatory Breast Cancer Clinic and Research Program, the University of Texas MD Anderson Cancer CenterMorgan Welch Inflammatory Breast Cancer Clinic and Research Program, the University of Texas MD Anderson Cancer CenterDepartment of Breast Medical Oncology, the University of Texas MD Anderson Cancer CenterMorgan Welch Inflammatory Breast Cancer Clinic and Research Program, the University of Texas MD Anderson Cancer CenterDepartment of Biostatistics, the University of Texas MD Anderson Cancer CenterMorgan Welch Inflammatory Breast Cancer Clinic and Research Program, the University of Texas MD Anderson Cancer CenterDepartment of Breast Medical Oncology, the University of Texas MD Anderson Cancer CenterDepartment of Breast Medical Oncology, the University of Texas MD Anderson Cancer CenterMorgan Welch Inflammatory Breast Cancer Clinic and Research Program, the University of Texas MD Anderson Cancer CenterDepartment of Breast Medical Oncology, the University of Texas MD Anderson Cancer CenterXiaoding Hu et al. find that expression of the proteoglycan decorin is decreased in patients with inflammatory breast cancer compared to normal breast tissue and some other types of breast cancer. They demonstrate that decorin acts as a tumor suppressor in cancer cells and human xenograft mouse models by destabilizing the E-cadherin-EGFR signaling axis, and their findings suggest potential therapeutic strategies for this aggressive breast cancer.https://doi.org/10.1038/s42003-020-01590-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xiaoding Hu Emilly S. Villodre Richard Larson Omar M. Rahal Xiaoping Wang Yun Gong Juhee Song Savitri Krishnamurthy Naoto T. Ueno Debu Tripathy Wendy A. Woodward Bisrat G. Debeb
spellingShingle	Xiaoding Hu Emilly S. Villodre Richard Larson Omar M. Rahal Xiaoping Wang Yun Gong Juhee Song Savitri Krishnamurthy Naoto T. Ueno Debu Tripathy Wendy A. Woodward Bisrat G. Debeb Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer Communications Biology
author_facet	Xiaoding Hu Emilly S. Villodre Richard Larson Omar M. Rahal Xiaoping Wang Yun Gong Juhee Song Savitri Krishnamurthy Naoto T. Ueno Debu Tripathy Wendy A. Woodward Bisrat G. Debeb
author_sort	Xiaoding Hu
title	Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer
title_short	Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer
title_full	Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer
title_fullStr	Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer
title_full_unstemmed	Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer
title_sort	decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-01-01
description	Xiaoding Hu et al. find that expression of the proteoglycan decorin is decreased in patients with inflammatory breast cancer compared to normal breast tissue and some other types of breast cancer. They demonstrate that decorin acts as a tumor suppressor in cancer cells and human xenograft mouse models by destabilizing the E-cadherin-EGFR signaling axis, and their findings suggest potential therapeutic strategies for this aggressive breast cancer.
url	https://doi.org/10.1038/s42003-020-01590-0
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Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer

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