Ambient fine particulate matter inhibits 15-lipoxygenases to promote lung carcinogenesis

Ambient fine particulate matter inhibits 15-lipoxygenases to promote lung carcinogenesis

Abstract Background Epidemiological observations have demonstrated that ambient fine particulate matter with d p < 2.5 μm (PM2.5) as the major factor responsible for the increasing incidence of lung cancer in never-smokers. However, there are very limited experimental data to support the associat...

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Bibliographic Details
Main Authors: Ming-Yue Li, Li-Zhong Liu, Wende Li, Calvin S. H. Ng, Yi Liu, Angel W. Y. Kong, Zhili Zhao, Shanshan Wang, Haolong Qi, Hao Jia, Shucai Yang, Jing Du, Xiang Long, Rocky L. K. Ho, Ernest C. W. Chak, Innes Y. P. Wan, Tony S. K. Mok, Malcolm J. Underwood, Nirmal Kumar Gali, Zhi Ning, George G. Chen
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Lung cancer
PM2.5
NNK
15-lipoxygenases (15-LOXs)
Epigenetic and post-translational regulation
Online Access:http://link.springer.com/article/10.1186/s13046-019-1380-z

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