Cellular Location of HNF4α is Linked With Terminal Liver Failure in Humans

Cellular Location of HNF4α is Linked With Terminal Liver Failure in Humans

Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor that plays a critical role in hepatocyte function, and HNF4α‐based reprogramming corrects terminal liver failure in rats with chronic liver disease. In the livers of patients with advanced cirrhosis, HNF4α RNA expression levels decr...

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Main Authors: Rodrigo M. Florentino, Nicolas A. Fraunhoffer, Kazutoyo Morita, Kazuki Takeishi, Alina Ostrowska, Abhinav Achreja, Olamide Animasahun, Nils Haep, Shohrat Arazov, Nandini Agarwal, Alexandra Collin de l'Hortet, Jorge Guzman‐Lepe, Edgar N. Tafaleng, Amitava Mukherjee, Kris Troy, Swati Banerjee, Shirish Paranjpe, George K. Michalopoulos, Aaron Bell, Deepak Nagrath, Sarah J. Hainer, Ira J. Fox, Alejandro Soto‐Gutierrez
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Hepatology Communications
Online Access:https://doi.org/10.1002/hep4.1505

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