RNA SEQ Analysis Indicates that the AE3 Cl−/HCO3 − Exchanger Contributes to Active Transport-Mediated CO2 Disposal in Heart

Abstract Loss of the AE3 Cl−/HCO3 − exchanger (Slc4a3) in mice causes an impaired cardiac force-frequency response and heart failure under some conditions but the mechanisms are not known. To better understand the functions of AE3, we performed RNA Seq analysis of AE3-null and wild-type mouse hearts...

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Bibliographic Details
Main Authors: Kanimozhi Vairamani, Hong-Sheng Wang, Mario Medvedovic, John N. Lorenz, Gary E. Shull
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07585-y

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