Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism

Rianne van Outersterp et al. combine mass spectrometry, NMR, and infrared ion spectroscopy to identify amino acid-hexose conjugates in the blood plasma from patients with metabolic disorders such as phenylketonuria (PKU). These conjugates, or Amadori rearrangement products, are generally not detecta...

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Main Authors:	Rianne E. van Outersterp, Sam J. Moons, Udo F. H. Engelke, Herman Bentlage, Tessa M. A. Peters, Arno van Rooij, Marleen C. D. G. Huigen, Siebolt de Boer, Ed van der Heeft, Leo A. J. Kluijtmans, Clara D. M. van Karnebeek, Ron A. Wevers, Giel Berden, Jos Oomens, Thomas J. Boltje, Karlien L. M. Coene, Jonathan Martens
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-03-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-01909-5

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spelling	doaj-a3702831608e413ca3c44c8e50fdc0d32021-03-21T12:28:55ZengNature Publishing GroupCommunications Biology2399-36422021-03-01411810.1038/s42003-021-01909-5Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolismRianne E. van Outersterp0Sam J. Moons1Udo F. H. Engelke2Herman Bentlage3Tessa M. A. Peters4Arno van Rooij5Marleen C. D. G. Huigen6Siebolt de Boer7Ed van der Heeft8Leo A. J. Kluijtmans9Clara D. M. van Karnebeek10Ron A. Wevers11Giel Berden12Jos Oomens13Thomas J. Boltje14Karlien L. M. Coene15Jonathan Martens16Radboud University, Institute for Molecules and Materials, FELIX Laboratory, Toernooiveld 7Radboud University, Institute for Molecules and Materials, Synthetic Organic ChemistryDepartment of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical CenterRadboud University, Institute for Molecules and Materials, FELIX Laboratory, Toernooiveld 7Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical CenterDepartment of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical CenterDepartment of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical CenterDepartment of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical CenterDepartment of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical CenterDepartment of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical CenterDepartment of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University Medical CenterDepartment of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical CenterRadboud University, Institute for Molecules and Materials, FELIX Laboratory, Toernooiveld 7Radboud University, Institute for Molecules and Materials, FELIX Laboratory, Toernooiveld 7Radboud University, Institute for Molecules and Materials, Synthetic Organic ChemistryDepartment of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical CenterRadboud University, Institute for Molecules and Materials, FELIX Laboratory, Toernooiveld 7Rianne van Outersterp et al. combine mass spectrometry, NMR, and infrared ion spectroscopy to identify amino acid-hexose conjugates in the blood plasma from patients with metabolic disorders such as phenylketonuria (PKU). These conjugates, or Amadori rearrangement products, are generally not detectable in blood samples from unaffected individuals, and may therefore represent disease biomarkers.https://doi.org/10.1038/s42003-021-01909-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rianne E. van Outersterp Sam J. Moons Udo F. H. Engelke Herman Bentlage Tessa M. A. Peters Arno van Rooij Marleen C. D. G. Huigen Siebolt de Boer Ed van der Heeft Leo A. J. Kluijtmans Clara D. M. van Karnebeek Ron A. Wevers Giel Berden Jos Oomens Thomas J. Boltje Karlien L. M. Coene Jonathan Martens
spellingShingle	Rianne E. van Outersterp Sam J. Moons Udo F. H. Engelke Herman Bentlage Tessa M. A. Peters Arno van Rooij Marleen C. D. G. Huigen Siebolt de Boer Ed van der Heeft Leo A. J. Kluijtmans Clara D. M. van Karnebeek Ron A. Wevers Giel Berden Jos Oomens Thomas J. Boltje Karlien L. M. Coene Jonathan Martens Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism Communications Biology
author_facet	Rianne E. van Outersterp Sam J. Moons Udo F. H. Engelke Herman Bentlage Tessa M. A. Peters Arno van Rooij Marleen C. D. G. Huigen Siebolt de Boer Ed van der Heeft Leo A. J. Kluijtmans Clara D. M. van Karnebeek Ron A. Wevers Giel Berden Jos Oomens Thomas J. Boltje Karlien L. M. Coene Jonathan Martens
author_sort	Rianne E. van Outersterp
title	Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism
title_short	Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism
title_full	Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism
title_fullStr	Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism
title_full_unstemmed	Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism
title_sort	amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-03-01
description	Rianne van Outersterp et al. combine mass spectrometry, NMR, and infrared ion spectroscopy to identify amino acid-hexose conjugates in the blood plasma from patients with metabolic disorders such as phenylketonuria (PKU). These conjugates, or Amadori rearrangement products, are generally not detectable in blood samples from unaffected individuals, and may therefore represent disease biomarkers.
url	https://doi.org/10.1038/s42003-021-01909-5
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Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism

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