Transforming growth factor β receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction
<p>Abstract</p> <p>Background</p> <p>Prediction of left ventricular (LV) remodeling after acute myocardial infarction (MI) is clinically important and would benefit from the discovery of new biomarkers.</p> <p>Methods</p> <p>Blood samples were ob...
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doaj-a37634554a48497296a81d41eb6a423c2021-04-02T10:52:25ZengBMCBMC Medical Genomics1755-87942011-12-01418310.1186/1755-8794-4-83Transforming growth factor β receptor 1 is a new candidate prognostic biomarker after acute myocardial infarctionDevaux YvanBousquenaud MelanieRodius SophieMarie Pierre-YvesMaskali FatihaZhang LuAzuaje FranciscoWagner Daniel R<p>Abstract</p> <p>Background</p> <p>Prediction of left ventricular (LV) remodeling after acute myocardial infarction (MI) is clinically important and would benefit from the discovery of new biomarkers.</p> <p>Methods</p> <p>Blood samples were obtained upon admission in patients with acute ST-elevation MI who underwent primary percutaneous coronary intervention. Messenger RNA was extracted from whole blood cells. LV function was evaluated by echocardiography at 4-months.</p> <p>Results</p> <p>In a test cohort of 32 MI patients, integrated analysis of microarrays with a network of protein-protein interactions identified subgroups of genes which predicted LV dysfunction (ejection fraction ≤ 40%) with areas under the receiver operating characteristic curve (AUC) above 0.80. Candidate genes included transforming growth factor beta receptor 1 (TGFBR1). In a validation cohort of 115 MI patients, TGBFR1 was up-regulated in patients with LV dysfunction (P < 0.001) and was associated with LV function at 4-months (P = 0.003). TGFBR1 predicted LV function with an AUC of 0.72, while peak levels of troponin T (TnT) provided an AUC of 0.64. Adding TGFBR1 to the prediction of TnT resulted in a net reclassification index of 8.2%. When added to a mixed clinical model including age, gender and time to reperfusion, TGFBR1 reclassified 17.7% of misclassified patients. TGFB1, the ligand of TGFBR1, was also up-regulated in patients with LV dysfunction (P = 0.004), was associated with LV function (P = 0.006), and provided an AUC of 0.66. In the rat MI model induced by permanent coronary ligation, the TGFB1-TGFBR1 axis was activated in the heart and correlated with the extent of remodeling at 2 months.</p> <p>Conclusions</p> <p>We identified TGFBR1 as a new candidate prognostic biomarker after acute MI.</p> http://www.biomedcentral.com/1755-8794/4/83 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Devaux Yvan Bousquenaud Melanie Rodius Sophie Marie Pierre-Yves Maskali Fatiha Zhang Lu Azuaje Francisco Wagner Daniel R |
spellingShingle |
Devaux Yvan Bousquenaud Melanie Rodius Sophie Marie Pierre-Yves Maskali Fatiha Zhang Lu Azuaje Francisco Wagner Daniel R Transforming growth factor β receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction BMC Medical Genomics |
author_facet |
Devaux Yvan Bousquenaud Melanie Rodius Sophie Marie Pierre-Yves Maskali Fatiha Zhang Lu Azuaje Francisco Wagner Daniel R |
author_sort |
Devaux Yvan |
title |
Transforming growth factor β receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction |
title_short |
Transforming growth factor β receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction |
title_full |
Transforming growth factor β receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction |
title_fullStr |
Transforming growth factor β receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction |
title_full_unstemmed |
Transforming growth factor β receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction |
title_sort |
transforming growth factor β receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction |
publisher |
BMC |
series |
BMC Medical Genomics |
issn |
1755-8794 |
publishDate |
2011-12-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Prediction of left ventricular (LV) remodeling after acute myocardial infarction (MI) is clinically important and would benefit from the discovery of new biomarkers.</p> <p>Methods</p> <p>Blood samples were obtained upon admission in patients with acute ST-elevation MI who underwent primary percutaneous coronary intervention. Messenger RNA was extracted from whole blood cells. LV function was evaluated by echocardiography at 4-months.</p> <p>Results</p> <p>In a test cohort of 32 MI patients, integrated analysis of microarrays with a network of protein-protein interactions identified subgroups of genes which predicted LV dysfunction (ejection fraction ≤ 40%) with areas under the receiver operating characteristic curve (AUC) above 0.80. Candidate genes included transforming growth factor beta receptor 1 (TGFBR1). In a validation cohort of 115 MI patients, TGBFR1 was up-regulated in patients with LV dysfunction (P < 0.001) and was associated with LV function at 4-months (P = 0.003). TGFBR1 predicted LV function with an AUC of 0.72, while peak levels of troponin T (TnT) provided an AUC of 0.64. Adding TGFBR1 to the prediction of TnT resulted in a net reclassification index of 8.2%. When added to a mixed clinical model including age, gender and time to reperfusion, TGFBR1 reclassified 17.7% of misclassified patients. TGFB1, the ligand of TGFBR1, was also up-regulated in patients with LV dysfunction (P = 0.004), was associated with LV function (P = 0.006), and provided an AUC of 0.66. In the rat MI model induced by permanent coronary ligation, the TGFB1-TGFBR1 axis was activated in the heart and correlated with the extent of remodeling at 2 months.</p> <p>Conclusions</p> <p>We identified TGFBR1 as a new candidate prognostic biomarker after acute MI.</p> |
url |
http://www.biomedcentral.com/1755-8794/4/83 |
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