MCM3AP-AS1: An Indispensable Cancer-Related LncRNA
Long non-coding RNAs (lncRNAs) are a class of RNA molecules with transcripts longer than 200 nucleotides that have no protein-coding ability. MCM3AP-AS1, a novel lncRNA, is aberrantly expressed in human cancers. It is significantly associated with many clinical characteristics, such as tumor size, t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.752718/full |
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| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xiao Yu Xiao Yu Xiao Yu Xiao Yu Qingyuan Zheng Qingyuan Zheng Qingyuan Zheng Qingyuan Zheng Qiyao Zhang Qiyao Zhang Qiyao Zhang Qiyao Zhang Shuijun Zhang Shuijun Zhang Shuijun Zhang Shuijun Zhang Yuting He Yuting He Yuting He Yuting He Wenzhi Guo Wenzhi Guo Wenzhi Guo Wenzhi Guo |
| spellingShingle |
Xiao Yu Xiao Yu Xiao Yu Xiao Yu Qingyuan Zheng Qingyuan Zheng Qingyuan Zheng Qingyuan Zheng Qiyao Zhang Qiyao Zhang Qiyao Zhang Qiyao Zhang Shuijun Zhang Shuijun Zhang Shuijun Zhang Shuijun Zhang Yuting He Yuting He Yuting He Yuting He Wenzhi Guo Wenzhi Guo Wenzhi Guo Wenzhi Guo MCM3AP-AS1: An Indispensable Cancer-Related LncRNA Frontiers in Cell and Developmental Biology long non-coding RNA MCM3AP-AS1 biological function regulatory mechanism biomarker |
| author_facet |
Xiao Yu Xiao Yu Xiao Yu Xiao Yu Qingyuan Zheng Qingyuan Zheng Qingyuan Zheng Qingyuan Zheng Qiyao Zhang Qiyao Zhang Qiyao Zhang Qiyao Zhang Shuijun Zhang Shuijun Zhang Shuijun Zhang Shuijun Zhang Yuting He Yuting He Yuting He Yuting He Wenzhi Guo Wenzhi Guo Wenzhi Guo Wenzhi Guo |
| author_sort |
Xiao Yu |
| title |
MCM3AP-AS1: An Indispensable Cancer-Related LncRNA |
| title_short |
MCM3AP-AS1: An Indispensable Cancer-Related LncRNA |
| title_full |
MCM3AP-AS1: An Indispensable Cancer-Related LncRNA |
| title_fullStr |
MCM3AP-AS1: An Indispensable Cancer-Related LncRNA |
| title_full_unstemmed |
MCM3AP-AS1: An Indispensable Cancer-Related LncRNA |
| title_sort |
mcm3ap-as1: an indispensable cancer-related lncrna |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Cell and Developmental Biology |
| issn |
2296-634X |
| publishDate |
2021-10-01 |
| description |
Long non-coding RNAs (lncRNAs) are a class of RNA molecules with transcripts longer than 200 nucleotides that have no protein-coding ability. MCM3AP-AS1, a novel lncRNA, is aberrantly expressed in human cancers. It is significantly associated with many clinical characteristics, such as tumor size, tumor-node-metastasis (TNM) stage, and pathological grade. Additionally, it considerably promotes or suppresses tumor progression by controlling the biological functions of cells. MCM3AP-AS1 is a promising biomarker for cancer diagnosis, prognosis evaluation, and treatment. In this review, we briefly summarized the published studies on the expression, biological function, and regulatory mechanisms of MCM3AP-AS1. We also discussed the clinical applications of MCM3AP-AS1 as a biomarker. |
| topic |
long non-coding RNA MCM3AP-AS1 biological function regulatory mechanism biomarker |
| url |
https://www.frontiersin.org/articles/10.3389/fcell.2021.752718/full |
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doaj-a37f9872bbcf48129efe262d549a79142021-10-07T06:49:55ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-10-01910.3389/fcell.2021.752718752718MCM3AP-AS1: An Indispensable Cancer-Related LncRNAXiao Yu0Xiao Yu1Xiao Yu2Xiao Yu3Qingyuan Zheng4Qingyuan Zheng5Qingyuan Zheng6Qingyuan Zheng7Qiyao Zhang8Qiyao Zhang9Qiyao Zhang10Qiyao Zhang11Shuijun Zhang12Shuijun Zhang13Shuijun Zhang14Shuijun Zhang15Yuting He16Yuting He17Yuting He18Yuting He19Wenzhi Guo20Wenzhi Guo21Wenzhi Guo22Wenzhi Guo23Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaOpen and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, ChinaHenan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaOpen and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, ChinaHenan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaOpen and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, ChinaHenan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaOpen and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, ChinaHenan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaOpen and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, ChinaHenan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaOpen and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, ChinaHenan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, ChinaLong non-coding RNAs (lncRNAs) are a class of RNA molecules with transcripts longer than 200 nucleotides that have no protein-coding ability. MCM3AP-AS1, a novel lncRNA, is aberrantly expressed in human cancers. It is significantly associated with many clinical characteristics, such as tumor size, tumor-node-metastasis (TNM) stage, and pathological grade. Additionally, it considerably promotes or suppresses tumor progression by controlling the biological functions of cells. MCM3AP-AS1 is a promising biomarker for cancer diagnosis, prognosis evaluation, and treatment. In this review, we briefly summarized the published studies on the expression, biological function, and regulatory mechanisms of MCM3AP-AS1. We also discussed the clinical applications of MCM3AP-AS1 as a biomarker.https://www.frontiersin.org/articles/10.3389/fcell.2021.752718/fulllong non-coding RNAMCM3AP-AS1biological functionregulatory mechanismbiomarker |