Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion.

Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion.

The recently identified restriction factor tetherin/BST-2/CD317 is an interferon-inducible trans-membrane protein that restricts HIV-1 particle release in the absence of the HIV-1 countermeasure viral protein U (Vpu). It is known that Tantalus monkey CV1 cells can be rendered non-permissive to HIV-1...

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Bibliographic Details
Main Authors:	Ravindra K Gupta, Stéphane Hué, Torsten Schaller, Ernst Verschoor, Deenan Pillay, Greg J Towers
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2009-05-01
Series:	PLoS Pathogens
Online Access:	http://europepmc.org/articles/PMC2678251?pdf=render

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