Defense peptides: recent developments
Defense peptides are small amphipathic molecules that exhibit antimicrobial, antitumor, antiviral, and immunomodulatory properties. This review summarizes current knowledge on the mechanisms of antimicrobial activity of cationic and anionic defense peptides, indicating peptide-based as well as micro...
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2015-08-01
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Online Access: | https://doi.org/10.1515/bmc-2015-0014 |
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doaj-a381e27dc21f4f93a354012c81729b132021-09-05T20:42:34ZengDe GruyterBiomolecular Concepts1868-50211868-503X2015-08-016423725110.1515/bmc-2015-0014Defense peptides: recent developmentsCytryńska Małgorzata0Zdybicka-Barabas Agnieszka1Faculty of Biology and Biotechnology, Institute of Biology and Biochemistry, Department of Immunobiology, Maria Curie-Skłodowska University, Akademicka 19 St., 20-033 Lublin, PolandFaculty of Biology and Biotechnology, Institute of Biology and Biochemistry, Department of Immunobiology, Maria Curie-Skłodowska University, Akademicka 19 St., 20-033 Lublin, PolandDefense peptides are small amphipathic molecules that exhibit antimicrobial, antitumor, antiviral, and immunomodulatory properties. This review summarizes current knowledge on the mechanisms of antimicrobial activity of cationic and anionic defense peptides, indicating peptide-based as well as microbial cell-based factors affecting this activity. The peptide-based factors include charge, hydrophibicity, and amphipathicity, whereas the pathogen-based factors are membrane lipid composition, presence of sterols, membrane fluidity, cell wall components, and secreted factors such as extracellular proteinases. Since defense peptides have been considered very promising molecules that could replace conventional antibiotics in the era of drug-resistant pathogens, the issue of microbial resistance to antimicrobial peptides (AMPs) is addressed. Furthermore, selected approaches employed for optimization and de novo design of effective AMPs based on the properties recognized as important for the function of natural defense peptides are presented.https://doi.org/10.1515/bmc-2015-0014amphipathicityanionic defense peptidesantimicrobial peptidesbacterial resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cytryńska Małgorzata Zdybicka-Barabas Agnieszka |
spellingShingle |
Cytryńska Małgorzata Zdybicka-Barabas Agnieszka Defense peptides: recent developments Biomolecular Concepts amphipathicity anionic defense peptides antimicrobial peptides bacterial resistance |
author_facet |
Cytryńska Małgorzata Zdybicka-Barabas Agnieszka |
author_sort |
Cytryńska Małgorzata |
title |
Defense peptides: recent developments |
title_short |
Defense peptides: recent developments |
title_full |
Defense peptides: recent developments |
title_fullStr |
Defense peptides: recent developments |
title_full_unstemmed |
Defense peptides: recent developments |
title_sort |
defense peptides: recent developments |
publisher |
De Gruyter |
series |
Biomolecular Concepts |
issn |
1868-5021 1868-503X |
publishDate |
2015-08-01 |
description |
Defense peptides are small amphipathic molecules that exhibit antimicrobial, antitumor, antiviral, and immunomodulatory properties. This review summarizes current knowledge on the mechanisms of antimicrobial activity of cationic and anionic defense peptides, indicating peptide-based as well as microbial cell-based factors affecting this activity. The peptide-based factors include charge, hydrophibicity, and amphipathicity, whereas the pathogen-based factors are membrane lipid composition, presence of sterols, membrane fluidity, cell wall components, and secreted factors such as extracellular proteinases. Since defense peptides have been considered very promising molecules that could replace conventional antibiotics in the era of drug-resistant pathogens, the issue of microbial resistance to antimicrobial peptides (AMPs) is addressed. Furthermore, selected approaches employed for optimization and de novo design of effective AMPs based on the properties recognized as important for the function of natural defense peptides are presented. |
topic |
amphipathicity anionic defense peptides antimicrobial peptides bacterial resistance |
url |
https://doi.org/10.1515/bmc-2015-0014 |
work_keys_str_mv |
AT cytrynskamałgorzata defensepeptidesrecentdevelopments AT zdybickabarabasagnieszka defensepeptidesrecentdevelopments |
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1717785419973656576 |