Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery

Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery

Deubiquitinase (DUB) is an essential component in the ubiquitin—proteasome system (UPS) by removing ubiquitin chains from substrates, thus modulating the expression, activity, and localization of many proteins that contribute to tumor development and progression. DUBs have emerged as promising progn...

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Main Authors: Sixuan Li, Hongquan Zhang, Xiaofan Wei
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Life
Subjects:
deubiquitinase
breast cancer
tumor growth and metastasis
cancer therapy
Online Access:https://www.mdpi.com/2075-1729/11/9/965
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spelling doaj-a3844beb441046f49b5822f6169621df2021-09-26T00:34:31ZengMDPI AGLife2075-17292021-09-011196596510.3390/life11090965Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug DiscoverySixuan Li0Hongquan Zhang1Xiaofan Wei2Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking Unversity Health Science Center, Beijing 100191, ChinaDepartment of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking Unversity Health Science Center, Beijing 100191, ChinaDepartment of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking Unversity Health Science Center, Beijing 100191, ChinaDeubiquitinase (DUB) is an essential component in the ubiquitin—proteasome system (UPS) by removing ubiquitin chains from substrates, thus modulating the expression, activity, and localization of many proteins that contribute to tumor development and progression. DUBs have emerged as promising prognostic indicators and drug targets. DUBs have shown significant roles in regulating breast cancer growth, metastasis, resistance to current therapies, and several canonical oncogenic signaling pathways. In addition, specific DUB inhibitors have been identified and are expected to benefit breast cancer patients in the future. Here, we review current knowledge about the effects and molecular mechanisms of DUBs in breast cancer, providing novel insight into treatments of breast cancer-targeting DUBs.https://www.mdpi.com/2075-1729/11/9/965deubiquitinasebreast cancertumor growth and metastasiscancer therapy
collection DOAJ
language English
format Article
sources DOAJ
author Sixuan Li
Hongquan Zhang
Xiaofan Wei
spellingShingle Sixuan Li
Hongquan Zhang
Xiaofan Wei
Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery
Life
deubiquitinase
breast cancer
tumor growth and metastasis
cancer therapy
author_facet Sixuan Li
Hongquan Zhang
Xiaofan Wei
author_sort Sixuan Li
title Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery
title_short Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery
title_full Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery
title_fullStr Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery
title_full_unstemmed Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery
title_sort roles and mechanisms of deubiquitinases (dubs) in breast cancer progression and targeted drug discovery
publisher MDPI AG
series Life
issn 2075-1729
publishDate 2021-09-01
description Deubiquitinase (DUB) is an essential component in the ubiquitin—proteasome system (UPS) by removing ubiquitin chains from substrates, thus modulating the expression, activity, and localization of many proteins that contribute to tumor development and progression. DUBs have emerged as promising prognostic indicators and drug targets. DUBs have shown significant roles in regulating breast cancer growth, metastasis, resistance to current therapies, and several canonical oncogenic signaling pathways. In addition, specific DUB inhibitors have been identified and are expected to benefit breast cancer patients in the future. Here, we review current knowledge about the effects and molecular mechanisms of DUBs in breast cancer, providing novel insight into treatments of breast cancer-targeting DUBs.
topic deubiquitinase
breast cancer
tumor growth and metastasis
cancer therapy
url https://www.mdpi.com/2075-1729/11/9/965
work_keys_str_mv AT sixuanli rolesandmechanismsofdeubiquitinasesdubsinbreastcancerprogressionandtargeteddrugdiscovery
AT hongquanzhang rolesandmechanismsofdeubiquitinasesdubsinbreastcancerprogressionandtargeteddrugdiscovery
AT xiaofanwei rolesandmechanismsofdeubiquitinasesdubsinbreastcancerprogressionandtargeteddrugdiscovery
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