Epigenetic Changes as a Target in Aging Haematopoietic Stem Cells and Age-Related Malignancies
Aging is associated with multiple molecular and functional changes in haematopoietic cells. Most notably, the self-renewal and differentiation potential of hematopoietic stem cells (HSCs) are compromised, resulting in myeloid skewing, reduced output of red blood cells and decreased generation of imm...
Main Authors: | Sonja C. Buisman, Gerald de Haan |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-08-01
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Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/8/8/868 |
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