The role of Ca2+/calmodulin-dependent protein kinase II and calcineurin in TNF-α-induced myocardial hypertrophy
We investigated whether Ca2+/calmodulin-dependent kinase II (CaMKII) and calcineurin (CaN) are involved in myocardial hypertrophy induced by tumor necrosis factor α (TNF-α). The cardiomyocytes of neonatal Wistar rats (1-2 days old) were cultured and stimulated by TNF-α (100 μg/L), and Ca2+ signal tr...
Main Authors: | Gui-Jun Wang, Hong-Xin Wang, Yu-Sheng Yao, Lian-Yi Guo, Pei Liu |
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Format: | Article |
Language: | English |
Published: |
Associação Brasileira de Divulgação Científica
2012-11-01
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Series: | Brazilian Journal of Medical and Biological Research |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001100008&lng=en&tlng=en |
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