Association of Serum Calcium Levels with Infarct Size in Acute Ischemic Stroke: Observations from Northeast India
Background: Calcium is known to be major mediator in ischemic neuronal cell death. Recent studies have shown that elevated serum calcium levels at admission in patients with stroke have been associated with less severe clinical deficits and with better outcomes. Aim: The aim of this to determine the...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2016-12-01
|
Series: | Journal of Neurosciences in Rural Practice |
Subjects: | |
Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/0976-3147.196461 |
id |
doaj-a398563e32e5418aac9ac050eaf297f2 |
---|---|
record_format |
Article |
spelling |
doaj-a398563e32e5418aac9ac050eaf297f22021-04-02T12:08:46ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Neurosciences in Rural Practice0976-31470976-31552016-12-0107S041S04510.4103/0976-3147.196461Association of Serum Calcium Levels with Infarct Size in Acute Ischemic Stroke: Observations from Northeast IndiaMeghna Borah0Sriparna Dhar1Dipankar Mall Gogoi2Alice Abraham Ruram3Department of Biochemistry, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, IndiaDepartment of Radiology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, IndiaDepartment of Pharmacology, Assam Medical College and Hospital, Dibrugarh, Assam, IndiaDepartment of Radiology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, IndiaBackground: Calcium is known to be major mediator in ischemic neuronal cell death. Recent studies have shown that elevated serum calcium levels at admission in patients with stroke have been associated with less severe clinical deficits and with better outcomes. Aim: The aim of this to determine the correlation between serum calcium (total, corrected, and ionized) and infarct size (IS) in patients with acute ischemic stroke. Materials and Methods: Data were collected from 61 patients presenting with acute ischemic stroke from May 2015 to April 2016 at a tertiary care institute in Northeast India. Only patients aged ≥40 years and diagnosed as having acute ischemic cerebrovascular stroke with clinical examination and confirmed by a computed tomography scan were included in the study. Serum calcium levels (total, albumin corrected, and ionized) were collapsed into quartiles, and these quartile versions were used for calculating correlation. Pearson’s correlation coefficient was used for comparing calcium levels with IS. Results: Total calcium, albumin-corrected calcium, and ionized calcium had a statistically significant negative correlation with IS with r = −0.578, −0.5396, and −0.5335, respectively. Total and ionized calcium showed a significant negative correlation with IS across all four quartiles. Albumin-corrected calcium levels showed a significant negative correlation with IS only across the lowest and highest quartiles. Conclusion: The findings in our study suggest that serum calcium can be used as a prognostic indicator in ischemic stroke as its levels directly correlates with the IS.http://www.thieme-connect.de/DOI/DOI?10.4103/0976-3147.196461 acute ischemic stroke albumin-corrected calcium infarct size ionized calcium total calcium |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meghna Borah Sriparna Dhar Dipankar Mall Gogoi Alice Abraham Ruram |
spellingShingle |
Meghna Borah Sriparna Dhar Dipankar Mall Gogoi Alice Abraham Ruram Association of Serum Calcium Levels with Infarct Size in Acute Ischemic Stroke: Observations from Northeast India Journal of Neurosciences in Rural Practice acute ischemic stroke albumin-corrected calcium infarct size ionized calcium total calcium |
author_facet |
Meghna Borah Sriparna Dhar Dipankar Mall Gogoi Alice Abraham Ruram |
author_sort |
Meghna Borah |
title |
Association of Serum Calcium Levels with Infarct Size in Acute Ischemic Stroke: Observations from Northeast India |
title_short |
Association of Serum Calcium Levels with Infarct Size in Acute Ischemic Stroke: Observations from Northeast India |
title_full |
Association of Serum Calcium Levels with Infarct Size in Acute Ischemic Stroke: Observations from Northeast India |
title_fullStr |
Association of Serum Calcium Levels with Infarct Size in Acute Ischemic Stroke: Observations from Northeast India |
title_full_unstemmed |
Association of Serum Calcium Levels with Infarct Size in Acute Ischemic Stroke: Observations from Northeast India |
title_sort |
association of serum calcium levels with infarct size in acute ischemic stroke: observations from northeast india |
publisher |
Thieme Medical and Scientific Publishers Pvt. Ltd. |
series |
Journal of Neurosciences in Rural Practice |
issn |
0976-3147 0976-3155 |
publishDate |
2016-12-01 |
description |
Background: Calcium is known to be major mediator in ischemic neuronal cell death. Recent studies have shown that elevated serum calcium levels at admission in patients with stroke have been associated with less severe clinical deficits and with better outcomes. Aim: The aim of this to determine the correlation between serum calcium (total, corrected, and ionized) and infarct size (IS) in patients with acute ischemic stroke. Materials and Methods: Data were collected from 61 patients presenting with acute ischemic stroke from May 2015 to April 2016 at a tertiary care institute in Northeast India. Only patients aged ≥40 years and diagnosed as having acute ischemic cerebrovascular stroke with clinical examination and confirmed by a computed tomography scan were included in the study. Serum calcium levels (total, albumin corrected, and ionized) were collapsed into quartiles, and these quartile versions were used for calculating correlation. Pearson’s correlation coefficient was used for comparing calcium levels with IS. Results: Total calcium, albumin-corrected calcium, and ionized calcium had a statistically significant negative correlation with IS with r = −0.578, −0.5396, and −0.5335, respectively. Total and ionized calcium showed a significant negative correlation with IS across all four quartiles. Albumin-corrected calcium levels showed a significant negative correlation with IS only across the lowest and highest quartiles. Conclusion: The findings in our study suggest that serum calcium can be used as a prognostic indicator in ischemic stroke as its levels directly correlates with the IS. |
topic |
acute ischemic stroke albumin-corrected calcium infarct size ionized calcium total calcium |
url |
http://www.thieme-connect.de/DOI/DOI?10.4103/0976-3147.196461 |
work_keys_str_mv |
AT meghnaborah associationofserumcalciumlevelswithinfarctsizeinacuteischemicstrokeobservationsfromnortheastindia AT sriparnadhar associationofserumcalciumlevelswithinfarctsizeinacuteischemicstrokeobservationsfromnortheastindia AT dipankarmallgogoi associationofserumcalciumlevelswithinfarctsizeinacuteischemicstrokeobservationsfromnortheastindia AT aliceabrahamruram associationofserumcalciumlevelswithinfarctsizeinacuteischemicstrokeobservationsfromnortheastindia |
_version_ |
1721570071127523328 |