Homogeneous Biosensing Based on Magnetic Particle Labels
The growing availability of biomarker panels for molecular diagnostics is leading to an increasing need for fast and sensitive biosensing technologies that are applicable to point-of-care testing. In that regard, homogeneous measurement principles are especially relevant as they usually do not requi...
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doaj-a39e6b2254ba4622a270e77fd9056b662020-11-24T23:22:55ZengMDPI AGSensors1424-82202016-06-0116682810.3390/s16060828s16060828Homogeneous Biosensing Based on Magnetic Particle LabelsStefan Schrittwieser0Beatriz Pelaz1Wolfgang J. Parak2Sergio Lentijo-Mozo3Katerina Soulantica4Jan Dieckhoff5Frank Ludwig6Annegret Guenther7Andreas Tschöpe8Joerg Schotter9Molecular Diagnostics, AIT Austrian Institute of Technology, Vienna1220, AustriaFachbereich Physik, Philipps-Universität Marburg, Marburg 35037, GermanyFachbereich Physik, Philipps-Universität Marburg, Marburg 35037, GermanyLaboratoire de Physique et Chimie des Nano-objets (LPCNO), Université de Toulouse, INSA, UPS, CNRS, Toulouse 31077, FranceLaboratoire de Physique et Chimie des Nano-objets (LPCNO), Université de Toulouse, INSA, UPS, CNRS, Toulouse 31077, FranceInstitute of Electrical Measurement and Fundamental Electrical Engineering, TU Braunschweig, Braunschweig 38106, GermanyInstitute of Electrical Measurement and Fundamental Electrical Engineering, TU Braunschweig, Braunschweig 38106, GermanyExperimentalphysik, Universität des Saarlandes, Saarbrücken 66123, GermanyExperimentalphysik, Universität des Saarlandes, Saarbrücken 66123, GermanyMolecular Diagnostics, AIT Austrian Institute of Technology, Vienna1220, AustriaThe growing availability of biomarker panels for molecular diagnostics is leading to an increasing need for fast and sensitive biosensing technologies that are applicable to point-of-care testing. In that regard, homogeneous measurement principles are especially relevant as they usually do not require extensive sample preparation procedures, thus reducing the total analysis time and maximizing ease-of-use. In this review, we focus on homogeneous biosensors for the in vitro detection of biomarkers. Within this broad range of biosensors, we concentrate on methods that apply magnetic particle labels. The advantage of such methods lies in the added possibility to manipulate the particle labels by applied magnetic fields, which can be exploited, for example, to decrease incubation times or to enhance the signal-to-noise-ratio of the measurement signal by applying frequency-selective detection. In our review, we discriminate the corresponding methods based on the nature of the acquired measurement signal, which can either be based on magnetic or optical detection. The underlying measurement principles of the different techniques are discussed, and biosensing examples for all techniques are reported, thereby demonstrating the broad applicability of homogeneous in vitro biosensing based on magnetic particle label actuation.http://www.mdpi.com/1424-8220/16/6/828biosensormagnetic nanoparticlehomogeneous assaymagnetorelaxationAC susceptibilityNMRmagnetic relaxation switchasynchronous magnetorotationmagneto-opticsnanorod |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stefan Schrittwieser Beatriz Pelaz Wolfgang J. Parak Sergio Lentijo-Mozo Katerina Soulantica Jan Dieckhoff Frank Ludwig Annegret Guenther Andreas Tschöpe Joerg Schotter |
spellingShingle |
Stefan Schrittwieser Beatriz Pelaz Wolfgang J. Parak Sergio Lentijo-Mozo Katerina Soulantica Jan Dieckhoff Frank Ludwig Annegret Guenther Andreas Tschöpe Joerg Schotter Homogeneous Biosensing Based on Magnetic Particle Labels Sensors biosensor magnetic nanoparticle homogeneous assay magnetorelaxation AC susceptibility NMR magnetic relaxation switch asynchronous magnetorotation magneto-optics nanorod |
author_facet |
Stefan Schrittwieser Beatriz Pelaz Wolfgang J. Parak Sergio Lentijo-Mozo Katerina Soulantica Jan Dieckhoff Frank Ludwig Annegret Guenther Andreas Tschöpe Joerg Schotter |
author_sort |
Stefan Schrittwieser |
title |
Homogeneous Biosensing Based on Magnetic Particle Labels |
title_short |
Homogeneous Biosensing Based on Magnetic Particle Labels |
title_full |
Homogeneous Biosensing Based on Magnetic Particle Labels |
title_fullStr |
Homogeneous Biosensing Based on Magnetic Particle Labels |
title_full_unstemmed |
Homogeneous Biosensing Based on Magnetic Particle Labels |
title_sort |
homogeneous biosensing based on magnetic particle labels |
publisher |
MDPI AG |
series |
Sensors |
issn |
1424-8220 |
publishDate |
2016-06-01 |
description |
The growing availability of biomarker panels for molecular diagnostics is leading to an increasing need for fast and sensitive biosensing technologies that are applicable to point-of-care testing. In that regard, homogeneous measurement principles are especially relevant as they usually do not require extensive sample preparation procedures, thus reducing the total analysis time and maximizing ease-of-use. In this review, we focus on homogeneous biosensors for the in vitro detection of biomarkers. Within this broad range of biosensors, we concentrate on methods that apply magnetic particle labels. The advantage of such methods lies in the added possibility to manipulate the particle labels by applied magnetic fields, which can be exploited, for example, to decrease incubation times or to enhance the signal-to-noise-ratio of the measurement signal by applying frequency-selective detection. In our review, we discriminate the corresponding methods based on the nature of the acquired measurement signal, which can either be based on magnetic or optical detection. The underlying measurement principles of the different techniques are discussed, and biosensing examples for all techniques are reported, thereby demonstrating the broad applicability of homogeneous in vitro biosensing based on magnetic particle label actuation. |
topic |
biosensor magnetic nanoparticle homogeneous assay magnetorelaxation AC susceptibility NMR magnetic relaxation switch asynchronous magnetorotation magneto-optics nanorod |
url |
http://www.mdpi.com/1424-8220/16/6/828 |
work_keys_str_mv |
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