Cervical spine osteoradionecrosis or bone metastasis after radiotherapy for nasopharyngeal carcinoma? The MRI-based radiomics for characterization
Abstract Background To develop and validate an MRI-based radiomics nomogram for differentiation of cervical spine ORN from metastasis after radiotherapy (RT) in nasopharyngeal carcinoma (NPC). Methods A radiomics nomogram was developed in a training set that comprised 46 NPC patients after RT with 9...
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doaj-a3a3ae88520c4454a510ad6c29ed0ce52020-11-25T03:24:55ZengBMCBMC Medical Imaging1471-23422020-09-0120111110.1186/s12880-020-00502-2Cervical spine osteoradionecrosis or bone metastasis after radiotherapy for nasopharyngeal carcinoma? The MRI-based radiomics for characterizationXi Zhong0Li Li1Huali Jiang2Jinxue Yin3Bingui Lu4Wen Han5Jiansheng Li6Jian Zhang7Department of Medical Imaging, Affiliated Cancer Hospital & Institute of Guangzhou Medical UniversityDepartment of Otolaryngology, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Cardiovascularology, Tungwah Hospital of Sun Yat-Sen UniversityDepartment of Medical Imaging, Affiliated Cancer Hospital & Institute of Guangzhou Medical UniversityDepartment of Medical Imaging, Affiliated Cancer Hospital & Institute of Guangzhou Medical UniversityDepartment of Medical Imaging, Affiliated Cancer Hospital & Institute of Guangzhou Medical UniversityDepartment of Medical Imaging, Affiliated Cancer Hospital & Institute of Guangzhou Medical UniversityDepartment of Radiation Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical UniversityAbstract Background To develop and validate an MRI-based radiomics nomogram for differentiation of cervical spine ORN from metastasis after radiotherapy (RT) in nasopharyngeal carcinoma (NPC). Methods A radiomics nomogram was developed in a training set that comprised 46 NPC patients after RT with 95 cervical spine lesions (ORN, n = 51; metastasis, n = 44), and data were gathered from January 2008 to December 2012. 279 radiomics features were extracted from the axial contrast-enhanced T1-weighted image (CE-T1WI). A radiomics signature was created by using the least absolute shrinkage and selection operator (LASSO) algorithm. A nomogram model was developed based on the radiomics scores. The performance of the nomogram was determined in terms of its discrimination, calibration, and clinical utility. An independent validation set contained 25 consecutive patients with 47 lesions (ORN, n = 25; metastasis, n = 22) from January 2013 to December 2015. Results The radiomics signature that comprised eight selected features was significantly associated with the differentiation of cervical spine ORN and metastasis. The nomogram model demonstrated good calibration and discrimination in the training set [AUC, 0.725; 95% confidence interval (CI), 0.622–0.828] and the validation set (AUC, 0.720; 95% CI, 0.573–0.867). The decision curve analysis indicated that the radiomics nomogram was clinically useful. Conclusions MRI-based radiomics nomogram shows potential value to differentiate cervical spine ORN from metastasis after RT in NPC.http://link.springer.com/article/10.1186/s12880-020-00502-2Magnetic resonance imagingNasopharyngeal carcinomaRadiotherapyOsteoradionecrosisRadiomics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xi Zhong Li Li Huali Jiang Jinxue Yin Bingui Lu Wen Han Jiansheng Li Jian Zhang |
spellingShingle |
Xi Zhong Li Li Huali Jiang Jinxue Yin Bingui Lu Wen Han Jiansheng Li Jian Zhang Cervical spine osteoradionecrosis or bone metastasis after radiotherapy for nasopharyngeal carcinoma? The MRI-based radiomics for characterization BMC Medical Imaging Magnetic resonance imaging Nasopharyngeal carcinoma Radiotherapy Osteoradionecrosis Radiomics |
author_facet |
Xi Zhong Li Li Huali Jiang Jinxue Yin Bingui Lu Wen Han Jiansheng Li Jian Zhang |
author_sort |
Xi Zhong |
title |
Cervical spine osteoradionecrosis or bone metastasis after radiotherapy for nasopharyngeal carcinoma? The MRI-based radiomics for characterization |
title_short |
Cervical spine osteoradionecrosis or bone metastasis after radiotherapy for nasopharyngeal carcinoma? The MRI-based radiomics for characterization |
title_full |
Cervical spine osteoradionecrosis or bone metastasis after radiotherapy for nasopharyngeal carcinoma? The MRI-based radiomics for characterization |
title_fullStr |
Cervical spine osteoradionecrosis or bone metastasis after radiotherapy for nasopharyngeal carcinoma? The MRI-based radiomics for characterization |
title_full_unstemmed |
Cervical spine osteoradionecrosis or bone metastasis after radiotherapy for nasopharyngeal carcinoma? The MRI-based radiomics for characterization |
title_sort |
cervical spine osteoradionecrosis or bone metastasis after radiotherapy for nasopharyngeal carcinoma? the mri-based radiomics for characterization |
publisher |
BMC |
series |
BMC Medical Imaging |
issn |
1471-2342 |
publishDate |
2020-09-01 |
description |
Abstract Background To develop and validate an MRI-based radiomics nomogram for differentiation of cervical spine ORN from metastasis after radiotherapy (RT) in nasopharyngeal carcinoma (NPC). Methods A radiomics nomogram was developed in a training set that comprised 46 NPC patients after RT with 95 cervical spine lesions (ORN, n = 51; metastasis, n = 44), and data were gathered from January 2008 to December 2012. 279 radiomics features were extracted from the axial contrast-enhanced T1-weighted image (CE-T1WI). A radiomics signature was created by using the least absolute shrinkage and selection operator (LASSO) algorithm. A nomogram model was developed based on the radiomics scores. The performance of the nomogram was determined in terms of its discrimination, calibration, and clinical utility. An independent validation set contained 25 consecutive patients with 47 lesions (ORN, n = 25; metastasis, n = 22) from January 2013 to December 2015. Results The radiomics signature that comprised eight selected features was significantly associated with the differentiation of cervical spine ORN and metastasis. The nomogram model demonstrated good calibration and discrimination in the training set [AUC, 0.725; 95% confidence interval (CI), 0.622–0.828] and the validation set (AUC, 0.720; 95% CI, 0.573–0.867). The decision curve analysis indicated that the radiomics nomogram was clinically useful. Conclusions MRI-based radiomics nomogram shows potential value to differentiate cervical spine ORN from metastasis after RT in NPC. |
topic |
Magnetic resonance imaging Nasopharyngeal carcinoma Radiotherapy Osteoradionecrosis Radiomics |
url |
http://link.springer.com/article/10.1186/s12880-020-00502-2 |
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