Association between tumor necrosis factor alpha-238G/a polymorphism and tuberculosis susceptibility: a meta-analysis study

• Main Authors: Zhang Zhijiao, Zhu Hang, Pu Xudi, Meng Siying, Zhang Fan, Xun Lei, Liu Qin, Wang Yang
• Format: Article
• Language: English
• Published: BMC 2012-11-01
• Series: BMC Infectious Diseases
• Subjects: TNF-α; Polymorphism; Tuberculosis; Susceptibility; Meta-analysis
• Online Access: http://www.biomedcentral.com/1471-2334/12/328

<p>Abstract</p> <p>Background</p> <p>Tumor necrosis factor alpha (TNF-α) plays a key role in the containment of tuberculosis. The relationship between the TNF -238G/A polymorphism and tuberculosis susceptibility remains inconclusive. A comprehensive meta-analysis was made to provide a more precise estimate of the relationship between them.</p> <p>Methods</p> <p>Multiple search strategies were used. A fixed effect model was taken<it>took</it> to estimate pooled OR with 95% confidence interval (CI) for the association between the TNF -238G/A polymorphism and tuberculosis susceptibility. The Chi-squared-based Q-test and I-squared<it>I</it>^<it>2</it> statistic were calculated to examine heterogeneity. Begg’s funnel plot and Egger’s test were used to assess publication bias.</p> <p>Results</p> <p>9 case-control studies were included in this meta-analysis. No significant heterogeneity was demonstrated, and no obvious publication bias was detected among the included studies. The meta-analysis indicated that there was no significant association between the TNF -238G/A polymorphism and tuberculosis susceptibility (GA+AA versus GG model: OR=1.005, 95% CI: 0.765-1.319; A versus G model: OR=1.000, 95% CI: 0.769-1.300). In the subgroup analyses by ethnicity, types of TB and human immunodeficiency virus (HIV) status, no significant association were identified.</p> <p>Conclusions</p> <p>The meta-analysis involving 2723 subjects did not detect any association between the TNF -238G/A polymorphism and tuberculosis susceptibility.</p>