GPSM2 Serves as an Independent Prognostic Biomarker for Liver Cancer Survival
Background and Objective: Liver cancer is a malignancy with a poor prognosis. G protein signaling modulator 2 is mainly related to cell division and cell cycle regulation. In this review, the relationship between G protein signaling modulator 2 and clinical characteristics of patients with liver can...
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doaj-a3add4b9e624424e90ee12a68e7e6bbf2020-11-25T04:03:52ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382020-08-011910.1177/1533033820945817GPSM2 Serves as an Independent Prognostic Biomarker for Liver Cancer SurvivalDingquan Yang PhD0Fujian Ji MD1Yanqing Li PhD2Yan Jiao PhD3Xuedong Fang MD4 Department of Gastrointestinal Colorectal and Anal Surgery, , Changchun, Jilin, China Department of Gastrointestinal Colorectal and Anal Surgery, , Changchun, Jilin, China Department of Pathophysiology, College of Basic Medical Sciences, , Changchun, Jilin, China Department of Hepatobiliary and Pancreatic Surgery, , Changchun, Jilin, China Department of Gastrointestinal Colorectal and Anal Surgery, , Changchun, Jilin, ChinaBackground and Objective: Liver cancer is a malignancy with a poor prognosis. G protein signaling modulator 2 is mainly related to cell division and cell cycle regulation. In this review, the relationship between G protein signaling modulator 2 and clinical characteristics of patients with liver cancer has been explored, especially with respect to its prognostic value. Methods: G protein signaling modulator 2 messenger RNA expression and clinicopathological characteristics of patients with liver cancer were obtained from The Cancer Genome Atlas. The expression level of G protein signaling modulator 2 RNA-Seq was validated by using Gene Expression Omnibus. Chi-square test was performed to evaluate the relationship between G protein signaling modulator 2 expression and clinical characteristics. The threshold value of G protein signaling modulator 2 in the diagnosis of liver cancer was evaluated by a receiver–operating characteristic curve. Cox regression analysis and Kaplan-Meier curves were performed to evaluate the relationship between G protein signaling modulator 2 and liver cancer prognosis, which included overall and residual-free survival, and explored the prognostic value of G protein signaling modulator 2. Liver cancer survival analyses were validated by using the data of G protein signaling modulator 2 RNA-Seq from the International Cancer Genome Consortium. Results: The expression level of G protein signaling modulator 2 messenger RNA was remarkably higher in liver cancer than that in healthy tissues ( P < 2.2 × e −16 ), which was also validated by data from the GSE14520 database. In addition, high G protein signaling modulator 2 expression significantly correlated with histological grade ( P = .020), vital status ( P < .001), clinical ( P = .001), and T stage ( P = .001). The receiver–operating characteristic curves showed G protein signaling modulator 2 to be an advantageous diagnostic molecule for liver cancer (area under curve = 0.893). Furthermore, the results of Cox analysis and Kaplan-Meier curves suggested that the upregulation of G protein signaling modulator 2 expression is linked to poor prognosis and G protein signaling modulator 2 messenger RNA could be an independent predictor for liver cancer, which was validated by data from the International Cancer Genome Consortium database. Conclusions: G protein signaling modulator 2 messenger RNA was overexpressed in liver cancer, and G protein signaling modulator 2 is an independent prognostic factor. G protein signaling modulator 2 is expected to be a treatment target for cancer.https://doi.org/10.1177/1533033820945817 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dingquan Yang PhD Fujian Ji MD Yanqing Li PhD Yan Jiao PhD Xuedong Fang MD |
spellingShingle |
Dingquan Yang PhD Fujian Ji MD Yanqing Li PhD Yan Jiao PhD Xuedong Fang MD GPSM2 Serves as an Independent Prognostic Biomarker for Liver Cancer Survival Technology in Cancer Research & Treatment |
author_facet |
Dingquan Yang PhD Fujian Ji MD Yanqing Li PhD Yan Jiao PhD Xuedong Fang MD |
author_sort |
Dingquan Yang PhD |
title |
GPSM2 Serves as an Independent Prognostic Biomarker for Liver Cancer Survival |
title_short |
GPSM2 Serves as an Independent Prognostic Biomarker for Liver Cancer Survival |
title_full |
GPSM2 Serves as an Independent Prognostic Biomarker for Liver Cancer Survival |
title_fullStr |
GPSM2 Serves as an Independent Prognostic Biomarker for Liver Cancer Survival |
title_full_unstemmed |
GPSM2 Serves as an Independent Prognostic Biomarker for Liver Cancer Survival |
title_sort |
gpsm2 serves as an independent prognostic biomarker for liver cancer survival |
publisher |
SAGE Publishing |
series |
Technology in Cancer Research & Treatment |
issn |
1533-0338 |
publishDate |
2020-08-01 |
description |
Background and Objective: Liver cancer is a malignancy with a poor prognosis. G protein signaling modulator 2 is mainly related to cell division and cell cycle regulation. In this review, the relationship between G protein signaling modulator 2 and clinical characteristics of patients with liver cancer has been explored, especially with respect to its prognostic value. Methods: G protein signaling modulator 2 messenger RNA expression and clinicopathological characteristics of patients with liver cancer were obtained from The Cancer Genome Atlas. The expression level of G protein signaling modulator 2 RNA-Seq was validated by using Gene Expression Omnibus. Chi-square test was performed to evaluate the relationship between G protein signaling modulator 2 expression and clinical characteristics. The threshold value of G protein signaling modulator 2 in the diagnosis of liver cancer was evaluated by a receiver–operating characteristic curve. Cox regression analysis and Kaplan-Meier curves were performed to evaluate the relationship between G protein signaling modulator 2 and liver cancer prognosis, which included overall and residual-free survival, and explored the prognostic value of G protein signaling modulator 2. Liver cancer survival analyses were validated by using the data of G protein signaling modulator 2 RNA-Seq from the International Cancer Genome Consortium. Results: The expression level of G protein signaling modulator 2 messenger RNA was remarkably higher in liver cancer than that in healthy tissues ( P < 2.2 × e −16 ), which was also validated by data from the GSE14520 database. In addition, high G protein signaling modulator 2 expression significantly correlated with histological grade ( P = .020), vital status ( P < .001), clinical ( P = .001), and T stage ( P = .001). The receiver–operating characteristic curves showed G protein signaling modulator 2 to be an advantageous diagnostic molecule for liver cancer (area under curve = 0.893). Furthermore, the results of Cox analysis and Kaplan-Meier curves suggested that the upregulation of G protein signaling modulator 2 expression is linked to poor prognosis and G protein signaling modulator 2 messenger RNA could be an independent predictor for liver cancer, which was validated by data from the International Cancer Genome Consortium database. Conclusions: G protein signaling modulator 2 messenger RNA was overexpressed in liver cancer, and G protein signaling modulator 2 is an independent prognostic factor. G protein signaling modulator 2 is expected to be a treatment target for cancer. |
url |
https://doi.org/10.1177/1533033820945817 |
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