Establishment of an International Collaborative Network for N-of-1 Trials and Single-Case Designs
In this article we briefly examine the unique features of Single-Case Designs (SCDs) (studies in a single participant), their history and current trends, and real-world clinical applications. The International Collaborative Network for N-of-1 Trials and Single-Case Designs (ICN) is a formal collabor...
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doaj-a3b91a727f1348a49009824f1b66ce972021-09-13T04:14:32ZengElsevierContemporary Clinical Trials Communications2451-86542021-09-0123100826Establishment of an International Collaborative Network for N-of-1 Trials and Single-Case DesignsJane Nikles0Patrick Onghena1Johan W.S. Vlaeyen2Rikard K. Wicksell3Laura E. Simons4James M. McGree5Suzanne McDonald6Centre for Clinical Research, The University of Queensland, Australia; Corresponding author. University of Queensland Centre for Clinical Research, Building 71/918 RBWH Herston, Brisbane, QLD, 4029, Australia.KU Leuven, BelgiumKU Leuven, Belgium; University of Maastricht, the NetherlandsKarolinska Institute, SwedenStanford University Medical Centre, United StatesQueensland University of Technology, AustraliaCentre for Clinical Research, The University of Queensland, AustraliaIn this article we briefly examine the unique features of Single-Case Designs (SCDs) (studies in a single participant), their history and current trends, and real-world clinical applications. The International Collaborative Network for N-of-1 Trials and Single-Case Designs (ICN) is a formal collaborative network for individuals with an interest in SCDs. The ICN was established in 2017 to support the SCD scientific community and provide opportunities for collaboration, a global communication channel, resource sharing and knowledge exchange. In May 2021, there were more than 420 members in 31 countries. A member survey was undertaken in 2019 to identify priorities for the ICN for the following few years. This article outlines the key priorities identified and the ICN's progress to date in these key areas including network activities (developing a communications strategy to increase awareness, collecting/sharing a comprehensive set of resources, guidelines and tips, and incorporating the consumer perspective) and scientific activities (writing position papers and guest editing special journal issues, exploring key stakeholder perspectives about SCDs, and working to streamline ethical approval processes for SCDs). The ICN provides a practical means to engage with this methodology through membership. We encourage clinicians, researchers, industry, and healthcare consumers to learn more about and conduct SCDs, and to join us in our mission of using SCDs to improve health outcomes for individuals and populations.http://www.sciencedirect.com/science/article/pii/S2451865421001277N-of-1 trialsClinical trialsNetworkClinical trials networkSingle Case Experimental Design |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jane Nikles Patrick Onghena Johan W.S. Vlaeyen Rikard K. Wicksell Laura E. Simons James M. McGree Suzanne McDonald |
spellingShingle |
Jane Nikles Patrick Onghena Johan W.S. Vlaeyen Rikard K. Wicksell Laura E. Simons James M. McGree Suzanne McDonald Establishment of an International Collaborative Network for N-of-1 Trials and Single-Case Designs Contemporary Clinical Trials Communications N-of-1 trials Clinical trials Network Clinical trials network Single Case Experimental Design |
author_facet |
Jane Nikles Patrick Onghena Johan W.S. Vlaeyen Rikard K. Wicksell Laura E. Simons James M. McGree Suzanne McDonald |
author_sort |
Jane Nikles |
title |
Establishment of an International Collaborative Network for N-of-1 Trials and Single-Case Designs |
title_short |
Establishment of an International Collaborative Network for N-of-1 Trials and Single-Case Designs |
title_full |
Establishment of an International Collaborative Network for N-of-1 Trials and Single-Case Designs |
title_fullStr |
Establishment of an International Collaborative Network for N-of-1 Trials and Single-Case Designs |
title_full_unstemmed |
Establishment of an International Collaborative Network for N-of-1 Trials and Single-Case Designs |
title_sort |
establishment of an international collaborative network for n-of-1 trials and single-case designs |
publisher |
Elsevier |
series |
Contemporary Clinical Trials Communications |
issn |
2451-8654 |
publishDate |
2021-09-01 |
description |
In this article we briefly examine the unique features of Single-Case Designs (SCDs) (studies in a single participant), their history and current trends, and real-world clinical applications. The International Collaborative Network for N-of-1 Trials and Single-Case Designs (ICN) is a formal collaborative network for individuals with an interest in SCDs. The ICN was established in 2017 to support the SCD scientific community and provide opportunities for collaboration, a global communication channel, resource sharing and knowledge exchange. In May 2021, there were more than 420 members in 31 countries. A member survey was undertaken in 2019 to identify priorities for the ICN for the following few years. This article outlines the key priorities identified and the ICN's progress to date in these key areas including network activities (developing a communications strategy to increase awareness, collecting/sharing a comprehensive set of resources, guidelines and tips, and incorporating the consumer perspective) and scientific activities (writing position papers and guest editing special journal issues, exploring key stakeholder perspectives about SCDs, and working to streamline ethical approval processes for SCDs). The ICN provides a practical means to engage with this methodology through membership. We encourage clinicians, researchers, industry, and healthcare consumers to learn more about and conduct SCDs, and to join us in our mission of using SCDs to improve health outcomes for individuals and populations. |
topic |
N-of-1 trials Clinical trials Network Clinical trials network Single Case Experimental Design |
url |
http://www.sciencedirect.com/science/article/pii/S2451865421001277 |
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