The effect of genetic variations on ribavirin pharmacokinetics and treatment response in HCV-4 Egyptian patients receiving sofosbuvir/daclatasvir and ribavirin

The effect of genetic variations on ribavirin pharmacokinetics and treatment response in HCV-4 Egyptian patients receiving sofosbuvir/daclatasvir and ribavirin

Purpose: This study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) of genes involved in ribavirin (RBV) transport (SLC28A2 gene, ABCB1 gene and ABCB11 gene) on the clinical outcome and pharmacokinetics of ribavirin in HCV- 4 Egyptian patients. Method: 100 patients treated...

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Bibliographic Details
Main Authors: K.S. Abdelkawy, S.M. El-Haggar, D.H. Ziada, N.F. Ebaid, M.A. El-Magd, F.A. Elbarbry
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Ribavirin
Pharmacokinetics
ABCB1
ABCB11
Hepatitis C
SNP
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219352795

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