Common causes and characteristics of adverse drug reactions in older adults: a retrospective study
Abstract Background Aging populations are often accompanied by comorbidity and polypharmacy, leading to increases in adverse drug reactions (ADRs). We sought to evaluate the causes and characteristics of ADRs in older Korean adults (≥65 years) in comparison to younger individuals (< 65 years). Me...
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doaj-a3c917cb27284ee69e7697e782503fe72020-12-13T12:19:56ZengBMCBMC Pharmacology and Toxicology2050-65112020-12-012111910.1186/s40360-020-00464-9Common causes and characteristics of adverse drug reactions in older adults: a retrospective studySeong-Dae Woo0Jiwon Yoon1Go-Eun Doo2Youjin Park3Youngsoo Lee4So-Hee Lee5Young-Hee Lee6Young-Min Ye7Department of Allergy and Clinical Immunology, Ajou University School of MedicineAjou Regional Pharmacovigilance Center, Ajou University HospitalAjou Regional Pharmacovigilance Center, Ajou University HospitalDepartment of Biomedical Sciences, Ajou University Graduate School of MedicineDepartment of Allergy and Clinical Immunology, Ajou University School of MedicineDepartment of Allergy and Clinical Immunology, Ajou University School of MedicineAjou Regional Pharmacovigilance Center, Ajou University HospitalDepartment of Allergy and Clinical Immunology, Ajou University School of MedicineAbstract Background Aging populations are often accompanied by comorbidity and polypharmacy, leading to increases in adverse drug reactions (ADRs). We sought to evaluate the causes and characteristics of ADRs in older Korean adults (≥65 years) in comparison to younger individuals (< 65 years). Methods Of 37,523 cases reported at a Korean pharmacovigilance center from 2011 to 2018, we reviewed 18,842 ADRs of certain or probable causality on the basis of WHO-UMC criteria. We estimated the number of ADRs per 1000 patients exposed to the major culprit drugs, and incidence rate ratios were obtained to assess high- and low-risk medications in older adults. Results In total, 4152 (22.0%) ADRs were reported for 3437 older adults (mean age, 74.6 years and 57.3% female). Tramadol (rate ratio, 1.32; 95% confidence interval [CI], 1.21–1.44; P < 0.001) and fentanyl (1.49, 1.16–1.92, P = 0.002) posed higher risks of ADRs in the older adults, whereas nonsteroidal anti-inflammatory drugs (NSAIDs) (0.35, 0.30–0.40, P < 0.001) and iodinated contrast media (ICM) (0.82, 0.76–0.89, P < 0.001) posed lower risks. Ratios of serious ADRs to NSAIDs (odds ratio, 2.16; 95% CI, 1.48–3.15; P < 0.001) and ICM (2.09, 1.36–3.21, P = 0.001) were higher in the older adults than in the younger patients. Analgesics primarily elicited cutaneous ADRs in the younger patients and gastrointestinal reactions in the older adults. ICM more commonly led to anaphylaxis in the older adults than the younger patients (3.0% vs. 1.6%, P = 0.019). Conclusion For early detection of ADRs in older adults, better understanding of differences in the causes and characteristics thereof in comparison to the general population is needed.https://doi.org/10.1186/s40360-020-00464-9Adverse drug reactionAgedDrug hypersensitivityPharmacovigilance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Seong-Dae Woo Jiwon Yoon Go-Eun Doo Youjin Park Youngsoo Lee So-Hee Lee Young-Hee Lee Young-Min Ye |
spellingShingle |
Seong-Dae Woo Jiwon Yoon Go-Eun Doo Youjin Park Youngsoo Lee So-Hee Lee Young-Hee Lee Young-Min Ye Common causes and characteristics of adverse drug reactions in older adults: a retrospective study BMC Pharmacology and Toxicology Adverse drug reaction Aged Drug hypersensitivity Pharmacovigilance |
author_facet |
Seong-Dae Woo Jiwon Yoon Go-Eun Doo Youjin Park Youngsoo Lee So-Hee Lee Young-Hee Lee Young-Min Ye |
author_sort |
Seong-Dae Woo |
title |
Common causes and characteristics of adverse drug reactions in older adults: a retrospective study |
title_short |
Common causes and characteristics of adverse drug reactions in older adults: a retrospective study |
title_full |
Common causes and characteristics of adverse drug reactions in older adults: a retrospective study |
title_fullStr |
Common causes and characteristics of adverse drug reactions in older adults: a retrospective study |
title_full_unstemmed |
Common causes and characteristics of adverse drug reactions in older adults: a retrospective study |
title_sort |
common causes and characteristics of adverse drug reactions in older adults: a retrospective study |
publisher |
BMC |
series |
BMC Pharmacology and Toxicology |
issn |
2050-6511 |
publishDate |
2020-12-01 |
description |
Abstract Background Aging populations are often accompanied by comorbidity and polypharmacy, leading to increases in adverse drug reactions (ADRs). We sought to evaluate the causes and characteristics of ADRs in older Korean adults (≥65 years) in comparison to younger individuals (< 65 years). Methods Of 37,523 cases reported at a Korean pharmacovigilance center from 2011 to 2018, we reviewed 18,842 ADRs of certain or probable causality on the basis of WHO-UMC criteria. We estimated the number of ADRs per 1000 patients exposed to the major culprit drugs, and incidence rate ratios were obtained to assess high- and low-risk medications in older adults. Results In total, 4152 (22.0%) ADRs were reported for 3437 older adults (mean age, 74.6 years and 57.3% female). Tramadol (rate ratio, 1.32; 95% confidence interval [CI], 1.21–1.44; P < 0.001) and fentanyl (1.49, 1.16–1.92, P = 0.002) posed higher risks of ADRs in the older adults, whereas nonsteroidal anti-inflammatory drugs (NSAIDs) (0.35, 0.30–0.40, P < 0.001) and iodinated contrast media (ICM) (0.82, 0.76–0.89, P < 0.001) posed lower risks. Ratios of serious ADRs to NSAIDs (odds ratio, 2.16; 95% CI, 1.48–3.15; P < 0.001) and ICM (2.09, 1.36–3.21, P = 0.001) were higher in the older adults than in the younger patients. Analgesics primarily elicited cutaneous ADRs in the younger patients and gastrointestinal reactions in the older adults. ICM more commonly led to anaphylaxis in the older adults than the younger patients (3.0% vs. 1.6%, P = 0.019). Conclusion For early detection of ADRs in older adults, better understanding of differences in the causes and characteristics thereof in comparison to the general population is needed. |
topic |
Adverse drug reaction Aged Drug hypersensitivity Pharmacovigilance |
url |
https://doi.org/10.1186/s40360-020-00464-9 |
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