Exosomes from Plasma of Neuroblastoma Patients Contain Doublestranded DNA Reflecting the Mutational Status of Parental Tumor Cells

Exosomes from Plasma of Neuroblastoma Patients Contain Doublestranded DNA Reflecting the Mutational Status of Parental Tumor Cells

Neuroblastoma (NB) is an aggressive infancy tumor, leading cause of death among preschool age diseases. Here we focused on characterization of exosomal DNA (exo-DNA) isolated from plasma cell-derived exosomes of neuroblastoma patients, and its potential use for detection of somatic mutations present...

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Bibliographic Details
Main Authors: Chiara Degli Esposti, Barbara Iadarola, Simone Maestri, Cristina Beltrami, Denise Lavezzari, Martina Morini, Patrizia De Marco, Giovanni Erminio, Alberto Garaventa, Federico Zara, Massimo Delledonne, Marzia Ognibene, Annalisa Pezzolo
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
neuroblastoma
exosomes
exo-DNA
<i>ALK</i>
genotypability
tumor mutation load
Online Access:https://www.mdpi.com/1422-0067/22/7/3667

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