Epigenome editing strategies for the functional annotation of CTCF insulators

Epigenome editing strategies for the functional annotation of CTCF insulators

The role of CTCF-bound insulator elements in enhancer-gene interactions and transcriptional regulation remains poorly understood. Here, the authors investigate multiple epigenome editing strategies for perturbing individual CTCF-bound insulators, and evaluate their effects on genome topology and tra...

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Main Authors: Daniel R. Tarjan, William A. Flavahan, Bradley E. Bernstein
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12166-w
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spelling doaj-a3ca68a0d6b24effa3df235e4cfa56452021-05-11T11:33:31ZengNature Publishing GroupNature Communications2041-17232019-09-011011810.1038/s41467-019-12166-wEpigenome editing strategies for the functional annotation of CTCF insulatorsDaniel R. Tarjan0William A. Flavahan1Bradley E. Bernstein2Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical SchoolDepartment of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical SchoolDepartment of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical SchoolThe role of CTCF-bound insulator elements in enhancer-gene interactions and transcriptional regulation remains poorly understood. Here, the authors investigate multiple epigenome editing strategies for perturbing individual CTCF-bound insulators, and evaluate their effects on genome topology and transcription.https://doi.org/10.1038/s41467-019-12166-w
collection DOAJ
language English
format Article
sources DOAJ
author Daniel R. Tarjan
William A. Flavahan
Bradley E. Bernstein
spellingShingle Daniel R. Tarjan
William A. Flavahan
Bradley E. Bernstein
Epigenome editing strategies for the functional annotation of CTCF insulators
Nature Communications
author_facet Daniel R. Tarjan
William A. Flavahan
Bradley E. Bernstein
author_sort Daniel R. Tarjan
title Epigenome editing strategies for the functional annotation of CTCF insulators
title_short Epigenome editing strategies for the functional annotation of CTCF insulators
title_full Epigenome editing strategies for the functional annotation of CTCF insulators
title_fullStr Epigenome editing strategies for the functional annotation of CTCF insulators
title_full_unstemmed Epigenome editing strategies for the functional annotation of CTCF insulators
title_sort epigenome editing strategies for the functional annotation of ctcf insulators
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-09-01
description The role of CTCF-bound insulator elements in enhancer-gene interactions and transcriptional regulation remains poorly understood. Here, the authors investigate multiple epigenome editing strategies for perturbing individual CTCF-bound insulators, and evaluate their effects on genome topology and transcription.
url https://doi.org/10.1038/s41467-019-12166-w
work_keys_str_mv AT danielrtarjan epigenomeeditingstrategiesforthefunctionalannotationofctcfinsulators
AT williamaflavahan epigenomeeditingstrategiesforthefunctionalannotationofctcfinsulators
AT bradleyebernstein epigenomeeditingstrategiesforthefunctionalannotationofctcfinsulators
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