Epigenome editing strategies for the functional annotation of CTCF insulators
The role of CTCF-bound insulator elements in enhancer-gene interactions and transcriptional regulation remains poorly understood. Here, the authors investigate multiple epigenome editing strategies for perturbing individual CTCF-bound insulators, and evaluate their effects on genome topology and tra...
Main Authors: | Daniel R. Tarjan, William A. Flavahan, Bradley E. Bernstein |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-09-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-12166-w |
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