Notch2-mediated plasticity between marginal zone and follicular B cells

Notch2-mediated plasticity between marginal zone and follicular B cells

Notch signalling is central to marginal zone B cell development, but it is unclear what path this development takes in vivo. Here the authors use a mouse that lacks these cells to show that transgenic induction of Notch2 is sufficient for development of marginal zone B cells via transdifferentiation...

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Main Authors: Markus Lechner, Thomas Engleitner, Tea Babushku, Marc Schmidt-Supprian, Roland Rad, Lothar J. Strobl, Ursula Zimber-Strobl
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21359-1
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spelling doaj-a3cb7509c5204caea9c78545ccf138662021-02-21T12:13:42ZengNature Publishing GroupNature Communications2041-17232021-02-0112111310.1038/s41467-021-21359-1Notch2-mediated plasticity between marginal zone and follicular B cellsMarkus Lechner0Thomas Engleitner1Tea Babushku2Marc Schmidt-Supprian3Roland Rad4Lothar J. Strobl5Ursula Zimber-Strobl6Research Unit Gene Vectors, Helmholtz Zentrum München GmbH, German Research Center for Environmental HealthTranslaTUM, Center for Translational Cancer Research, Technical University of MunichResearch Unit Gene Vectors, Helmholtz Zentrum München GmbH, German Research Center for Environmental HealthTranslaTUM, Center for Translational Cancer Research, Technical University of MunichTranslaTUM, Center for Translational Cancer Research, Technical University of MunichResearch Unit Gene Vectors, Helmholtz Zentrum München GmbH, German Research Center for Environmental HealthResearch Unit Gene Vectors, Helmholtz Zentrum München GmbH, German Research Center for Environmental HealthNotch signalling is central to marginal zone B cell development, but it is unclear what path this development takes in vivo. Here the authors use a mouse that lacks these cells to show that transgenic induction of Notch2 is sufficient for development of marginal zone B cells via transdifferentiation from follicular B cells and that this mechanism can occur in wildtype mice.https://doi.org/10.1038/s41467-021-21359-1
collection DOAJ
language English
format Article
sources DOAJ
author Markus Lechner
Thomas Engleitner
Tea Babushku
Marc Schmidt-Supprian
Roland Rad
Lothar J. Strobl
Ursula Zimber-Strobl
spellingShingle Markus Lechner
Thomas Engleitner
Tea Babushku
Marc Schmidt-Supprian
Roland Rad
Lothar J. Strobl
Ursula Zimber-Strobl
Notch2-mediated plasticity between marginal zone and follicular B cells
Nature Communications
author_facet Markus Lechner
Thomas Engleitner
Tea Babushku
Marc Schmidt-Supprian
Roland Rad
Lothar J. Strobl
Ursula Zimber-Strobl
author_sort Markus Lechner
title Notch2-mediated plasticity between marginal zone and follicular B cells
title_short Notch2-mediated plasticity between marginal zone and follicular B cells
title_full Notch2-mediated plasticity between marginal zone and follicular B cells
title_fullStr Notch2-mediated plasticity between marginal zone and follicular B cells
title_full_unstemmed Notch2-mediated plasticity between marginal zone and follicular B cells
title_sort notch2-mediated plasticity between marginal zone and follicular b cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-02-01
description Notch signalling is central to marginal zone B cell development, but it is unclear what path this development takes in vivo. Here the authors use a mouse that lacks these cells to show that transgenic induction of Notch2 is sufficient for development of marginal zone B cells via transdifferentiation from follicular B cells and that this mechanism can occur in wildtype mice.
url https://doi.org/10.1038/s41467-021-21359-1
work_keys_str_mv AT markuslechner notch2mediatedplasticitybetweenmarginalzoneandfollicularbcells
AT thomasengleitner notch2mediatedplasticitybetweenmarginalzoneandfollicularbcells
AT teababushku notch2mediatedplasticitybetweenmarginalzoneandfollicularbcells
AT marcschmidtsupprian notch2mediatedplasticitybetweenmarginalzoneandfollicularbcells
AT rolandrad notch2mediatedplasticitybetweenmarginalzoneandfollicularbcells
AT lotharjstrobl notch2mediatedplasticitybetweenmarginalzoneandfollicularbcells
AT ursulazimberstrobl notch2mediatedplasticitybetweenmarginalzoneandfollicularbcells
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