Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome
The Bacillus haemolytic enterotoxin haemolysin BL has been shown to activate the NLRP3 inflammasome. Here the authors show that a non-haemolytic enterotoxin (NHE) from B. cereus can also activate the NLRP3 inflammasome with a similar mechanism of lytic pore formation.
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| Format: | Article |
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Nature Publishing Group
2020-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14534-3 |
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doaj-a3d1c668fd514f4c9ccf1972f0c941e92021-05-11T09:04:34ZengNature Publishing GroupNature Communications2041-17232020-02-0111111610.1038/s41467-020-14534-3Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasomeDaniel Fox0Anukriti Mathur1Yansong Xue2Yunqi Liu3Wei Hong Tan4Shouya Feng5Abhimanu Pandey6Chinh Ngo7Jenni A. Hayward8Ines I. Atmosukarto9Jason D. Price10Matthew D. Johnson11Nadja Jessberger12Avril A. B. Robertson13Gaetan Burgio14David C. Tscharke15Edward M. Fox16Denisse L. Leyton17Nadeem O. Kaakoush18Erwin Märtlbauer19Stephen H. Leppla20Si Ming Man21Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National UniversityDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National UniversityDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National UniversityDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National UniversityDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National UniversityDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National UniversityDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National UniversityDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National UniversityDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National UniversityLipotek Pty Ltd. The John Curtin School of Medical Research, The Australian National UniversityLipotek Pty Ltd. The John Curtin School of Medical Research, The Australian National UniversityResearch School of Biology, The Australian National UniversityDepartment of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität MünchenSchool of Chemistry and Molecular Biosciences, The University of QueenslandDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National UniversityDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National UniversityDepartment of Applied Sciences, Northumbria UniversityResearch School of Biology, The Australian National UniversitySchool of Medical Sciences, UNSW SydneyDepartment of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität MünchenMicrobial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthDepartment of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National UniversityThe Bacillus haemolytic enterotoxin haemolysin BL has been shown to activate the NLRP3 inflammasome. Here the authors show that a non-haemolytic enterotoxin (NHE) from B. cereus can also activate the NLRP3 inflammasome with a similar mechanism of lytic pore formation.https://doi.org/10.1038/s41467-020-14534-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Daniel Fox Anukriti Mathur Yansong Xue Yunqi Liu Wei Hong Tan Shouya Feng Abhimanu Pandey Chinh Ngo Jenni A. Hayward Ines I. Atmosukarto Jason D. Price Matthew D. Johnson Nadja Jessberger Avril A. B. Robertson Gaetan Burgio David C. Tscharke Edward M. Fox Denisse L. Leyton Nadeem O. Kaakoush Erwin Märtlbauer Stephen H. Leppla Si Ming Man |
| spellingShingle |
Daniel Fox Anukriti Mathur Yansong Xue Yunqi Liu Wei Hong Tan Shouya Feng Abhimanu Pandey Chinh Ngo Jenni A. Hayward Ines I. Atmosukarto Jason D. Price Matthew D. Johnson Nadja Jessberger Avril A. B. Robertson Gaetan Burgio David C. Tscharke Edward M. Fox Denisse L. Leyton Nadeem O. Kaakoush Erwin Märtlbauer Stephen H. Leppla Si Ming Man Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome Nature Communications |
| author_facet |
Daniel Fox Anukriti Mathur Yansong Xue Yunqi Liu Wei Hong Tan Shouya Feng Abhimanu Pandey Chinh Ngo Jenni A. Hayward Ines I. Atmosukarto Jason D. Price Matthew D. Johnson Nadja Jessberger Avril A. B. Robertson Gaetan Burgio David C. Tscharke Edward M. Fox Denisse L. Leyton Nadeem O. Kaakoush Erwin Märtlbauer Stephen H. Leppla Si Ming Man |
| author_sort |
Daniel Fox |
| title |
Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome |
| title_short |
Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome |
| title_full |
Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome |
| title_fullStr |
Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome |
| title_full_unstemmed |
Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome |
| title_sort |
bacillus cereus non-haemolytic enterotoxin activates the nlrp3 inflammasome |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-02-01 |
| description |
The Bacillus haemolytic enterotoxin haemolysin BL has been shown to activate the NLRP3 inflammasome. Here the authors show that a non-haemolytic enterotoxin (NHE) from B. cereus can also activate the NLRP3 inflammasome with a similar mechanism of lytic pore formation. |
| url |
https://doi.org/10.1038/s41467-020-14534-3 |
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