Association between Preoperative Long-Chain Polyunsaturated Fatty Acids and Oxidative Stress Immediately after Total Knee Arthroplasty: A Pilot Study
Quadriceps muscle atrophy following total knee arthroplasty (TKA) can be caused by tourniquet-induced ischemia–reperfusion (IR) injury, which is often accompanied by oxidative stress and inflammatory responses. <i>n</i>-3 long-chain polyunsaturated fatty acids (LCPUFAs), such as eicosape...
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doaj-a3d7cc877ad14990a3ad1f639932d39e2021-07-01T00:36:14ZengMDPI AGNutrients2072-66432021-06-01132093209310.3390/nu13062093Association between Preoperative Long-Chain Polyunsaturated Fatty Acids and Oxidative Stress Immediately after Total Knee Arthroplasty: A Pilot StudyYusuke Kubo0Masae Ikeya1Shuhei Sugiyama2Rie Takachu3Maki Tanaka4Takeshi Sugiura5Kaori Kobori6Makoto Kobori7Department of Rehabilitation, Kobori Orthopedic Clinic, 548-2 Nearaichou, Kita-ku, Hamamatsu 433-8108, JapanDepartment of Health and Nutrition Sciences, Tokoha University, 1230, Miyakodachou, Kita-ku, Hamamatsu 431-2102, JapanDepartment of Rehabilitation, Kobori Orthopedic Clinic, 548-2 Nearaichou, Kita-ku, Hamamatsu 433-8108, JapanDepartment of Rehabilitation, Kobori Orthopedic Clinic, 548-2 Nearaichou, Kita-ku, Hamamatsu 433-8108, JapanRehabilitation Sciences, Seirei Christopher University, 3453 Mikataharachou, Kita-ku, Hamamatsu 433-8558, JapanDepartment of Rehabilitation, Kobori Orthopedic Clinic, 548-2 Nearaichou, Kita-ku, Hamamatsu 433-8108, JapanDepartment of Rehabilitation, Kobori Orthopedic Clinic, 548-2 Nearaichou, Kita-ku, Hamamatsu 433-8108, JapanDepartment of Rehabilitation, Kobori Orthopedic Clinic, 548-2 Nearaichou, Kita-ku, Hamamatsu 433-8108, JapanQuadriceps muscle atrophy following total knee arthroplasty (TKA) can be caused by tourniquet-induced ischemia–reperfusion (IR) injury, which is often accompanied by oxidative stress and inflammatory responses. <i>n</i>-3 long-chain polyunsaturated fatty acids (LCPUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), exert antioxidant and anti-inflammatory effects against IR injury, whereas <i>n</i>-6 LCPUFAs, particularly arachidonic acid (AA), exhibit pro-inflammatory effects and promote IR injury. This study aimed to examine whether preoperative serum EPA + DHA levels and the (EPA + DHA)/AA ratio are associated with oxidative stress immediately after TKA. Fourteen eligible patients with knee osteoarthritis scheduled for unilateral TKA participated in this study. The levels of serum EPA, DHA, and AA were measured immediately before surgery. Derivatives of reactive oxygen metabolites (d-ROMs) were used as biomarkers for oxidative stress. The preoperative serum EPA + DHA levels and the (EPA + DHA)/AA ratio were found to be significantly negatively correlated with the serum d-ROM levels at 96 h after surgery, and the rate of increase in serum d-ROM levels between baseline and 96 h postoperatively. This study suggested the preoperative serum EPA + DHA levels and the (EPA + DHA)/AA ratio can be negatively associated with oxidative stress immediately after TKA.https://www.mdpi.com/2072-6643/13/6/2093arachidonic aciddocosahexaenoic acideicosapentaenoic acidinflammationischemia–reperfusion injurymuscle atrophy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yusuke Kubo Masae Ikeya Shuhei Sugiyama Rie Takachu Maki Tanaka Takeshi Sugiura Kaori Kobori Makoto Kobori |
spellingShingle |
Yusuke Kubo Masae Ikeya Shuhei Sugiyama Rie Takachu Maki Tanaka Takeshi Sugiura Kaori Kobori Makoto Kobori Association between Preoperative Long-Chain Polyunsaturated Fatty Acids and Oxidative Stress Immediately after Total Knee Arthroplasty: A Pilot Study Nutrients arachidonic acid docosahexaenoic acid eicosapentaenoic acid inflammation ischemia–reperfusion injury muscle atrophy |
author_facet |
Yusuke Kubo Masae Ikeya Shuhei Sugiyama Rie Takachu Maki Tanaka Takeshi Sugiura Kaori Kobori Makoto Kobori |
author_sort |
Yusuke Kubo |
title |
Association between Preoperative Long-Chain Polyunsaturated Fatty Acids and Oxidative Stress Immediately after Total Knee Arthroplasty: A Pilot Study |
title_short |
Association between Preoperative Long-Chain Polyunsaturated Fatty Acids and Oxidative Stress Immediately after Total Knee Arthroplasty: A Pilot Study |
title_full |
Association between Preoperative Long-Chain Polyunsaturated Fatty Acids and Oxidative Stress Immediately after Total Knee Arthroplasty: A Pilot Study |
title_fullStr |
Association between Preoperative Long-Chain Polyunsaturated Fatty Acids and Oxidative Stress Immediately after Total Knee Arthroplasty: A Pilot Study |
title_full_unstemmed |
Association between Preoperative Long-Chain Polyunsaturated Fatty Acids and Oxidative Stress Immediately after Total Knee Arthroplasty: A Pilot Study |
title_sort |
association between preoperative long-chain polyunsaturated fatty acids and oxidative stress immediately after total knee arthroplasty: a pilot study |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-06-01 |
description |
Quadriceps muscle atrophy following total knee arthroplasty (TKA) can be caused by tourniquet-induced ischemia–reperfusion (IR) injury, which is often accompanied by oxidative stress and inflammatory responses. <i>n</i>-3 long-chain polyunsaturated fatty acids (LCPUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), exert antioxidant and anti-inflammatory effects against IR injury, whereas <i>n</i>-6 LCPUFAs, particularly arachidonic acid (AA), exhibit pro-inflammatory effects and promote IR injury. This study aimed to examine whether preoperative serum EPA + DHA levels and the (EPA + DHA)/AA ratio are associated with oxidative stress immediately after TKA. Fourteen eligible patients with knee osteoarthritis scheduled for unilateral TKA participated in this study. The levels of serum EPA, DHA, and AA were measured immediately before surgery. Derivatives of reactive oxygen metabolites (d-ROMs) were used as biomarkers for oxidative stress. The preoperative serum EPA + DHA levels and the (EPA + DHA)/AA ratio were found to be significantly negatively correlated with the serum d-ROM levels at 96 h after surgery, and the rate of increase in serum d-ROM levels between baseline and 96 h postoperatively. This study suggested the preoperative serum EPA + DHA levels and the (EPA + DHA)/AA ratio can be negatively associated with oxidative stress immediately after TKA. |
topic |
arachidonic acid docosahexaenoic acid eicosapentaenoic acid inflammation ischemia–reperfusion injury muscle atrophy |
url |
https://www.mdpi.com/2072-6643/13/6/2093 |
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