Increased proton pump inhibitor and NSAID exposure in irritable bowel syndrome: results from a case-control study
<p>Abstract</p> <p>Background</p> <p>Patients with irritable bowel syndrome (IBS) seen by a gastroenterologist often utilize medications that may alter intestinal homeostasis. The question arises whether exposure to these drugs is associated with the development of IBS...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2012-09-01
|
Series: | BMC Gastroenterology |
Subjects: | |
Online Access: | http://www.biomedcentral.com/1471-230X/12/121 |
id |
doaj-a3dbddaffb4649a48a11688da48dce4c |
---|---|
record_format |
Article |
spelling |
doaj-a3dbddaffb4649a48a11688da48dce4c2020-11-25T01:19:28ZengBMCBMC Gastroenterology1471-230X2012-09-0112112110.1186/1471-230X-12-121Increased proton pump inhibitor and NSAID exposure in irritable bowel syndrome: results from a case-control studyKeszthelyi DanielDackus Gwen HMasclee Gwen MKruimel Joanna WMasclee Ad AM<p>Abstract</p> <p>Background</p> <p>Patients with irritable bowel syndrome (IBS) seen by a gastroenterologist often utilize medications that may alter intestinal homeostasis. The question arises whether exposure to these drugs is associated with the development of IBS symptoms. Aim of this study was therefore to assess the use of PPIs and NSAIDs in patients with IBS versus controls.</p> <p>Methods</p> <p>Cases of IBS from the last 5 years were reviewed. All patients having had at least one prescription for a particular drug (PPIs, NSAIDs, SSRIs, diuretics, ACE inhibitors) in the 6 months prior to the time of initial symptom onset were considered exposed. The control group consisted of individuals randomly selected from the general population.</p> <p>Results</p> <p>287 cases of IBS were retrieved for analysis together with 287 age and sex-matched controls. Exposure to PPIs and NSAIDs was significantly higher in IBS patients, whereas no association between ACE inhibitor use and IBS was found. PPIs were not significantly associated when excluding patients with gastrointestinal reflux disease or functional dyspepsia. Exposure to SSRIs was also positively associated with IBS, but only when patients with psychiatric comorbidity were included in the analyses.</p> <p>Conclusions</p> <p>Medications that may alter intestinal homeostasis such as NSAIDs and PPIs were more frequently used in IBS patients compared to controls. This association might be relevant for everyday clinical practice, but it is remains to be elucidated whether this association is of etiological nature.</p> http://www.biomedcentral.com/1471-230X/12/121Irritable bowel syndromeProton pump inhibitorsNSAIDsSmall intestinal bacterial overgrowthIntestinal permeability |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Keszthelyi Daniel Dackus Gwen H Masclee Gwen M Kruimel Joanna W Masclee Ad AM |
spellingShingle |
Keszthelyi Daniel Dackus Gwen H Masclee Gwen M Kruimel Joanna W Masclee Ad AM Increased proton pump inhibitor and NSAID exposure in irritable bowel syndrome: results from a case-control study BMC Gastroenterology Irritable bowel syndrome Proton pump inhibitors NSAIDs Small intestinal bacterial overgrowth Intestinal permeability |
author_facet |
Keszthelyi Daniel Dackus Gwen H Masclee Gwen M Kruimel Joanna W Masclee Ad AM |
author_sort |
Keszthelyi Daniel |
title |
Increased proton pump inhibitor and NSAID exposure in irritable bowel syndrome: results from a case-control study |
title_short |
Increased proton pump inhibitor and NSAID exposure in irritable bowel syndrome: results from a case-control study |
title_full |
Increased proton pump inhibitor and NSAID exposure in irritable bowel syndrome: results from a case-control study |
title_fullStr |
Increased proton pump inhibitor and NSAID exposure in irritable bowel syndrome: results from a case-control study |
title_full_unstemmed |
Increased proton pump inhibitor and NSAID exposure in irritable bowel syndrome: results from a case-control study |
title_sort |
increased proton pump inhibitor and nsaid exposure in irritable bowel syndrome: results from a case-control study |
publisher |
BMC |
series |
BMC Gastroenterology |
issn |
1471-230X |
publishDate |
2012-09-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Patients with irritable bowel syndrome (IBS) seen by a gastroenterologist often utilize medications that may alter intestinal homeostasis. The question arises whether exposure to these drugs is associated with the development of IBS symptoms. Aim of this study was therefore to assess the use of PPIs and NSAIDs in patients with IBS versus controls.</p> <p>Methods</p> <p>Cases of IBS from the last 5 years were reviewed. All patients having had at least one prescription for a particular drug (PPIs, NSAIDs, SSRIs, diuretics, ACE inhibitors) in the 6 months prior to the time of initial symptom onset were considered exposed. The control group consisted of individuals randomly selected from the general population.</p> <p>Results</p> <p>287 cases of IBS were retrieved for analysis together with 287 age and sex-matched controls. Exposure to PPIs and NSAIDs was significantly higher in IBS patients, whereas no association between ACE inhibitor use and IBS was found. PPIs were not significantly associated when excluding patients with gastrointestinal reflux disease or functional dyspepsia. Exposure to SSRIs was also positively associated with IBS, but only when patients with psychiatric comorbidity were included in the analyses.</p> <p>Conclusions</p> <p>Medications that may alter intestinal homeostasis such as NSAIDs and PPIs were more frequently used in IBS patients compared to controls. This association might be relevant for everyday clinical practice, but it is remains to be elucidated whether this association is of etiological nature.</p> |
topic |
Irritable bowel syndrome Proton pump inhibitors NSAIDs Small intestinal bacterial overgrowth Intestinal permeability |
url |
http://www.biomedcentral.com/1471-230X/12/121 |
work_keys_str_mv |
AT keszthelyidaniel increasedprotonpumpinhibitorandnsaidexposureinirritablebowelsyndromeresultsfromacasecontrolstudy AT dackusgwenh increasedprotonpumpinhibitorandnsaidexposureinirritablebowelsyndromeresultsfromacasecontrolstudy AT mascleegwenm increasedprotonpumpinhibitorandnsaidexposureinirritablebowelsyndromeresultsfromacasecontrolstudy AT kruimeljoannaw increasedprotonpumpinhibitorandnsaidexposureinirritablebowelsyndromeresultsfromacasecontrolstudy AT mascleeadam increasedprotonpumpinhibitorandnsaidexposureinirritablebowelsyndromeresultsfromacasecontrolstudy |
_version_ |
1725138038362734592 |