Is zinc concentration in toxic phase plasma related to dengue severity and level of transaminases?

OBJECTIVE: To determine the relationship between plasma zinc values and the severity of dengue viral infection (DVI) and DVI-caused hepatitis. METHODS: A prospective cohort study was conducted during 2008-2010 in hospitalized children aged <15 years confirmed with DVI. Complete blood count, aspar...

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Main Authors: Kamolwish Laoprasopwattana, Chonthicha Tangcheewawatthanakul, Wanutsanun Tunyapanit, Rassamee Sangthong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3688526?pdf=render
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spelling doaj-a3de6a3d971b4eaba0f90a21f40472c42020-11-25T02:35:50ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352013-01-0176e228710.1371/journal.pntd.0002287Is zinc concentration in toxic phase plasma related to dengue severity and level of transaminases?Kamolwish LaoprasopwattanaChonthicha TangcheewawatthanakulWanutsanun TunyapanitRassamee SangthongOBJECTIVE: To determine the relationship between plasma zinc values and the severity of dengue viral infection (DVI) and DVI-caused hepatitis. METHODS: A prospective cohort study was conducted during 2008-2010 in hospitalized children aged <15 years confirmed with DVI. Complete blood count, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and zinc values (mcg/dL) were determined twice: first during the toxic phase (Zn1) and secondly two weeks after recovery (Zn2). RESULTS: 39 patients were enrolled with a mean age of 9.7 ± 3.7 years, and 15/39 diagnosed with dengue shock syndrome (DSS). Zn1 values were lower than Zn2 values [median (IQR): 46.0 (37.0, 58.0) vs 65.0 (58.0, 81.0) mcg/dL, respectively, p <0.01]. Zn1 but not Zn2 values had a negative correlation with AST and ALT (rs = -0.33, p = 0.04 and rs = -0.31, p = 0.05, respectively). Patients with DSS had lower Zn1 but not Zn2 values compared with non-DSS patients [median (IQR) Zn1, 38.0 (30.0, 48.0) vs 52.5 (41.2, 58.7), p = 0.02; Zn2, 61.0 (56.0, 88.0) vs 65.0 (59.5, 77.5), respectively, p = 0.76]. Zn1 values showed a decreasing trend across increasing dengue severity groups (p = 0.02). Age <5 years and DVI-associated diarrhea were associated with low Zn1. CONCLUSION: Children who had a higher grade of dengue disease severity and liver cell injury had lower Zn1 values. Low Zn1 values were probably caused by loss from diarrhea and from zinc translocating to liver cells.http://europepmc.org/articles/PMC3688526?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Kamolwish Laoprasopwattana
Chonthicha Tangcheewawatthanakul
Wanutsanun Tunyapanit
Rassamee Sangthong
spellingShingle Kamolwish Laoprasopwattana
Chonthicha Tangcheewawatthanakul
Wanutsanun Tunyapanit
Rassamee Sangthong
Is zinc concentration in toxic phase plasma related to dengue severity and level of transaminases?
PLoS Neglected Tropical Diseases
author_facet Kamolwish Laoprasopwattana
Chonthicha Tangcheewawatthanakul
Wanutsanun Tunyapanit
Rassamee Sangthong
author_sort Kamolwish Laoprasopwattana
title Is zinc concentration in toxic phase plasma related to dengue severity and level of transaminases?
title_short Is zinc concentration in toxic phase plasma related to dengue severity and level of transaminases?
title_full Is zinc concentration in toxic phase plasma related to dengue severity and level of transaminases?
title_fullStr Is zinc concentration in toxic phase plasma related to dengue severity and level of transaminases?
title_full_unstemmed Is zinc concentration in toxic phase plasma related to dengue severity and level of transaminases?
title_sort is zinc concentration in toxic phase plasma related to dengue severity and level of transaminases?
publisher Public Library of Science (PLoS)
series PLoS Neglected Tropical Diseases
issn 1935-2727
1935-2735
publishDate 2013-01-01
description OBJECTIVE: To determine the relationship between plasma zinc values and the severity of dengue viral infection (DVI) and DVI-caused hepatitis. METHODS: A prospective cohort study was conducted during 2008-2010 in hospitalized children aged <15 years confirmed with DVI. Complete blood count, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and zinc values (mcg/dL) were determined twice: first during the toxic phase (Zn1) and secondly two weeks after recovery (Zn2). RESULTS: 39 patients were enrolled with a mean age of 9.7 ± 3.7 years, and 15/39 diagnosed with dengue shock syndrome (DSS). Zn1 values were lower than Zn2 values [median (IQR): 46.0 (37.0, 58.0) vs 65.0 (58.0, 81.0) mcg/dL, respectively, p <0.01]. Zn1 but not Zn2 values had a negative correlation with AST and ALT (rs = -0.33, p = 0.04 and rs = -0.31, p = 0.05, respectively). Patients with DSS had lower Zn1 but not Zn2 values compared with non-DSS patients [median (IQR) Zn1, 38.0 (30.0, 48.0) vs 52.5 (41.2, 58.7), p = 0.02; Zn2, 61.0 (56.0, 88.0) vs 65.0 (59.5, 77.5), respectively, p = 0.76]. Zn1 values showed a decreasing trend across increasing dengue severity groups (p = 0.02). Age <5 years and DVI-associated diarrhea were associated with low Zn1. CONCLUSION: Children who had a higher grade of dengue disease severity and liver cell injury had lower Zn1 values. Low Zn1 values were probably caused by loss from diarrhea and from zinc translocating to liver cells.
url http://europepmc.org/articles/PMC3688526?pdf=render
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