Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological Approaches
The application of modeling and simulation (M&S) tools to biological, physiological, and clinical data has great potential to enhance drug development and regulatory decision making. The strategic development of multidisciplinary projects aimed at integrating methodologies from different discipl...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-06-01
|
| Series: | CPT: Pharmacometrics & Systems Pharmacology |
| Online Access: | https://doi.org/10.1002/psp4.12425 |
| id |
doaj-a3e76b8ec38a470a9af082611e69b03f |
|---|---|
| record_format |
Article |
| spelling |
doaj-a3e76b8ec38a470a9af082611e69b03f2020-11-25T02:49:31ZengWileyCPT: Pharmacometrics & Systems Pharmacology2163-83062019-06-018635235510.1002/psp4.12425Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological ApproachesStephan Schmidt0Sarah Kim1Valvanera Vozmediano2Rodrigo Cristofoletti3Almut G. Winterstein4Joshua D. Brown5Center for Pharmacometrics and Systems Pharmacology Department of Pharmaceutics College of Pharmacy University of Florida Orlando Florida USACenter for Pharmacometrics and Systems Pharmacology Department of Pharmaceutics College of Pharmacy University of Florida Orlando Florida USACenter for Pharmacometrics and Systems Pharmacology Department of Pharmaceutics College of Pharmacy University of Florida Orlando Florida USACenter for Pharmacometrics and Systems Pharmacology Department of Pharmaceutics College of Pharmacy University of Florida Orlando Florida USACenter for Drug Evaluation and Safety Department of Pharmaceutical Outcomes and Policy College of Pharmacy University of Florida Gainesville Florida USACenter for Drug Evaluation and Safety Department of Pharmaceutical Outcomes and Policy College of Pharmacy University of Florida Gainesville Florida USAThe application of modeling and simulation (M&S) tools to biological, physiological, and clinical data has great potential to enhance drug development and regulatory decision making. The strategic development of multidisciplinary projects aimed at integrating methodologies from different disciplines may bridge between preclinical and clinical drug development as well as between academic curiosity and clinical practice. Herein we review the history and present the state of M&S approaches as well as our vision for future challenges and applications.https://doi.org/10.1002/psp4.12425 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Stephan Schmidt Sarah Kim Valvanera Vozmediano Rodrigo Cristofoletti Almut G. Winterstein Joshua D. Brown |
| spellingShingle |
Stephan Schmidt Sarah Kim Valvanera Vozmediano Rodrigo Cristofoletti Almut G. Winterstein Joshua D. Brown Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological Approaches CPT: Pharmacometrics & Systems Pharmacology |
| author_facet |
Stephan Schmidt Sarah Kim Valvanera Vozmediano Rodrigo Cristofoletti Almut G. Winterstein Joshua D. Brown |
| author_sort |
Stephan Schmidt |
| title |
Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological Approaches |
| title_short |
Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological Approaches |
| title_full |
Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological Approaches |
| title_fullStr |
Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological Approaches |
| title_full_unstemmed |
Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological Approaches |
| title_sort |
pharmacometrics, physiologically based pharmacokinetics, quantitative systems pharmacology—what's next?—joining mechanistic and epidemiological approaches |
| publisher |
Wiley |
| series |
CPT: Pharmacometrics & Systems Pharmacology |
| issn |
2163-8306 |
| publishDate |
2019-06-01 |
| description |
The application of modeling and simulation (M&S) tools to biological, physiological, and clinical data has great potential to enhance drug development and regulatory decision making. The strategic development of multidisciplinary projects aimed at integrating methodologies from different disciplines may bridge between preclinical and clinical drug development as well as between academic curiosity and clinical practice. Herein we review the history and present the state of M&S approaches as well as our vision for future challenges and applications. |
| url |
https://doi.org/10.1002/psp4.12425 |
| work_keys_str_mv |
AT stephanschmidt pharmacometricsphysiologicallybasedpharmacokineticsquantitativesystemspharmacologywhatsnextjoiningmechanisticandepidemiologicalapproaches AT sarahkim pharmacometricsphysiologicallybasedpharmacokineticsquantitativesystemspharmacologywhatsnextjoiningmechanisticandepidemiologicalapproaches AT valvaneravozmediano pharmacometricsphysiologicallybasedpharmacokineticsquantitativesystemspharmacologywhatsnextjoiningmechanisticandepidemiologicalapproaches AT rodrigocristofoletti pharmacometricsphysiologicallybasedpharmacokineticsquantitativesystemspharmacologywhatsnextjoiningmechanisticandepidemiologicalapproaches AT almutgwinterstein pharmacometricsphysiologicallybasedpharmacokineticsquantitativesystemspharmacologywhatsnextjoiningmechanisticandepidemiologicalapproaches AT joshuadbrown pharmacometricsphysiologicallybasedpharmacokineticsquantitativesystemspharmacologywhatsnextjoiningmechanisticandepidemiologicalapproaches |
| _version_ |
1724742950133432320 |