Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?

Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?

The p53 tumor suppressor protein and its major negative regulators MDM2 and MDMX oncoproteins form the MDM2/MDMX-p53 circuitry, which plays critical roles in regulating cancer cell growth, proliferation, cell cycle progression, apoptosis, senescence, angiogenesis, and immune response. Recent studies...

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Bibliographic Details
Main Authors: Si-Min Qi, Gang Cheng, Xiang-Dong Cheng, Zhiyuan Xu, Beihua Xu, Wei-Dong Zhang, Jiang-Jiang Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
USP7
deubiquitination
p53
MDM2
MDMX
small-molecule inhibitor
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00233/full

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