Oxidative Stress in Obesity: A Critical Component in Human Diseases
Obesity, a social problem worldwide, is characterized by an increase in body weight that results in excessive fat accumulation. Obesity is a major cause of morbidity and mortality and leads to several diseases, including metabolic syndrome, diabetes mellitus, cardiovascular, fatty liver diseases, an...
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doaj-a3f151ea228c4b77b3908cde442de6942020-11-24T23:40:56ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-12-0116137840010.3390/ijms16010378ijms16010378Oxidative Stress in Obesity: A Critical Component in Human DiseasesLucia Marseglia0Sara Manti1Gabriella D’Angelo2Antonio Nicotera3Eleonora Parisi4Gabriella Di Rosa5Eloisa Gitto6Teresa Arrigo7Neonatal and Pediatric Intensive Care Unit, Department of Pediatrics, University of Messina, Via Consolare Valeria 1, 98125 Messina, ItalyUnit of Paediatric Genetics and Immunology, Department of Paediatrics, University of Messina, Via Consolare Valeria 1, 98125 Messina, ItalyNeonatal and Pediatric Intensive Care Unit, Department of Pediatrics, University of Messina, Via Consolare Valeria 1, 98125 Messina, ItalyUnit of Child Neurology and Psychiatry, Department of Pediatrics, University of Messina, Via Consolare Valeria 1, 98125 Messina, ItalyUnit of Child Neurology and Psychiatry, Department of Pediatrics, University of Messina, Via Consolare Valeria 1, 98125 Messina, ItalyUnit of Child Neurology and Psychiatry, Department of Pediatrics, University of Messina, Via Consolare Valeria 1, 98125 Messina, ItalyNeonatal and Pediatric Intensive Care Unit, Department of Pediatrics, University of Messina, Via Consolare Valeria 1, 98125 Messina, ItalyUnit of Paediatric Genetics and Immunology, Department of Paediatrics, University of Messina, Via Consolare Valeria 1, 98125 Messina, ItalyObesity, a social problem worldwide, is characterized by an increase in body weight that results in excessive fat accumulation. Obesity is a major cause of morbidity and mortality and leads to several diseases, including metabolic syndrome, diabetes mellitus, cardiovascular, fatty liver diseases, and cancer. Growing evidence allows us to understand the critical role of adipose tissue in controlling the physic-pathological mechanisms of obesity and related comorbidities. Recently, adipose tissue, especially in the visceral compartment, has been considered not only as a simple energy depository tissue, but also as an active endocrine organ releasing a variety of biologically active molecules known as adipocytokines or adipokines. Based on the complex interplay between adipokines, obesity is also characterized by chronic low grade inflammation with permanently increased oxidative stress (OS). Over-expression of oxidative stress damages cellular structures together with under-production of anti-oxidant mechanisms, leading to the development of obesity-related complications. The aim of this review is to summarize what is known in the relationship between OS in obesity and obesity-related diseases.http://www.mdpi.com/1422-0067/16/1/378obesityoxidative stressadipocytokineshuman diseasesadipose tissue |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lucia Marseglia Sara Manti Gabriella D’Angelo Antonio Nicotera Eleonora Parisi Gabriella Di Rosa Eloisa Gitto Teresa Arrigo |
spellingShingle |
Lucia Marseglia Sara Manti Gabriella D’Angelo Antonio Nicotera Eleonora Parisi Gabriella Di Rosa Eloisa Gitto Teresa Arrigo Oxidative Stress in Obesity: A Critical Component in Human Diseases International Journal of Molecular Sciences obesity oxidative stress adipocytokines human diseases adipose tissue |
author_facet |
Lucia Marseglia Sara Manti Gabriella D’Angelo Antonio Nicotera Eleonora Parisi Gabriella Di Rosa Eloisa Gitto Teresa Arrigo |
author_sort |
Lucia Marseglia |
title |
Oxidative Stress in Obesity: A Critical Component in Human Diseases |
title_short |
Oxidative Stress in Obesity: A Critical Component in Human Diseases |
title_full |
Oxidative Stress in Obesity: A Critical Component in Human Diseases |
title_fullStr |
Oxidative Stress in Obesity: A Critical Component in Human Diseases |
title_full_unstemmed |
Oxidative Stress in Obesity: A Critical Component in Human Diseases |
title_sort |
oxidative stress in obesity: a critical component in human diseases |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2014-12-01 |
description |
Obesity, a social problem worldwide, is characterized by an increase in body weight that results in excessive fat accumulation. Obesity is a major cause of morbidity and mortality and leads to several diseases, including metabolic syndrome, diabetes mellitus, cardiovascular, fatty liver diseases, and cancer. Growing evidence allows us to understand the critical role of adipose tissue in controlling the physic-pathological mechanisms of obesity and related comorbidities. Recently, adipose tissue, especially in the visceral compartment, has been considered not only as a simple energy depository tissue, but also as an active endocrine organ releasing a variety of biologically active molecules known as adipocytokines or adipokines. Based on the complex interplay between adipokines, obesity is also characterized by chronic low grade inflammation with permanently increased oxidative stress (OS). Over-expression of oxidative stress damages cellular structures together with under-production of anti-oxidant mechanisms, leading to the development of obesity-related complications. The aim of this review is to summarize what is known in the relationship between OS in obesity and obesity-related diseases. |
topic |
obesity oxidative stress adipocytokines human diseases adipose tissue |
url |
http://www.mdpi.com/1422-0067/16/1/378 |
work_keys_str_mv |
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