SI113, a Specific Inhibitor of the Sgk1 Kinase Activity that Counteracts Cancer Cell Proliferation

SI113, a Specific Inhibitor of the Sgk1 Kinase Activity that Counteracts Cancer Cell Proliferation

Background/Aims: Published observations on serum and glucocorticoid regulated kinase 1 (Sgk1) knockout murine models and Sgk1-specific RNA silencing in the RKO human colon carcinoma cell line point to this kinase as a central player in colon carcinogenesis and in resistance to taxanes. Methods: By i...

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Bibliographic Details
Main Authors: Lucia D''Antona, Rosario Amato, Cristina Talarico, Francesco Ortuso, Miranda Menniti, Vincenzo Dattilo, Rodolfo Iuliano, Francesco Gigliotti, Anna Artese, Giosuè Costa, Silvia Schenone, Francesca Musumeci, Claudia Abbruzzese, Lorenzo Botta, Francesco Trapasso, Stefano Alcaro, Marco G. Paggi, Nicola Perrotti
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
SGK1
Kinase inhibitor
Cancer
Necrosis
Small molecule
Apoptosis
Online Access:http://www.karger.com/Article/FullText/374008

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