The Mechanisms Underlying the Biological Response to Wear Debris in Periprosthetic Inflammation
Joint replacement surgery is the gold-standard therapeutic approach to treat patients with end-stage hip and knee arthritis, providing pain relief and joint function recovery. Despite the improvements in implant design and surgical techniques, revisions after total joint replacement are expected to...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-08-01
|
Series: | Frontiers in Materials |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fmats.2020.00274/full |
id |
doaj-a3fcf401b181488bbd4430be61a34a54 |
---|---|
record_format |
Article |
spelling |
doaj-a3fcf401b181488bbd4430be61a34a542020-11-25T03:51:34ZengFrontiers Media S.A.Frontiers in Materials2296-80162020-08-01710.3389/fmats.2020.00274551050The Mechanisms Underlying the Biological Response to Wear Debris in Periprosthetic InflammationMarina Couto0Marina Couto1Daniela P. Vasconcelos2Daniela P. Vasconcelos3Daniela M. Sousa4Daniela M. Sousa5Beatriz Sousa6Beatriz Sousa7Beatriz Sousa8Francisco Conceição9Francisco Conceição10Francisco Conceição11Estrela Neto12Estrela Neto13Meriem Lamghari14Meriem Lamghari15Meriem Lamghari16Cecília J. Alves17Cecília J. Alves18Instituto de Investigação e Inovação em Saúde da Universidade do Porto- Associação, Porto, PortugalInstituto de Engenharia Biomédica, Universidade do Porto, Porto, PortugalInstituto de Investigação e Inovação em Saúde da Universidade do Porto- Associação, Porto, PortugalInstituto de Engenharia Biomédica, Universidade do Porto, Porto, PortugalInstituto de Investigação e Inovação em Saúde da Universidade do Porto- Associação, Porto, PortugalInstituto de Engenharia Biomédica, Universidade do Porto, Porto, PortugalInstituto de Investigação e Inovação em Saúde da Universidade do Porto- Associação, Porto, PortugalInstituto de Engenharia Biomédica, Universidade do Porto, Porto, PortugalFaculdade de Engenharia, Universidade do Porto, Porto, PortugalInstituto de Investigação e Inovação em Saúde da Universidade do Porto- Associação, Porto, PortugalInstituto de Engenharia Biomédica, Universidade do Porto, Porto, PortugalInstituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, PortugalInstituto de Investigação e Inovação em Saúde da Universidade do Porto- Associação, Porto, PortugalInstituto de Engenharia Biomédica, Universidade do Porto, Porto, PortugalInstituto de Investigação e Inovação em Saúde da Universidade do Porto- Associação, Porto, PortugalInstituto de Engenharia Biomédica, Universidade do Porto, Porto, PortugalInstituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, PortugalInstituto de Investigação e Inovação em Saúde da Universidade do Porto- Associação, Porto, PortugalInstituto de Engenharia Biomédica, Universidade do Porto, Porto, PortugalJoint replacement surgery is the gold-standard therapeutic approach to treat patients with end-stage hip and knee arthritis, providing pain relief and joint function recovery. Despite the improvements in implant design and surgical techniques, revisions after total joint replacement are expected to grow. The periprosthetic inflammation, featured by the sustained inflammatory response to the implant debris, elicits the activation of osteoclasts and consequent periprosthetic osteolysis (PPOL), ultimately leading to implant aseptic loosening, which is the most common cause of long-term implant failure. There are currently no effective strategies to control periprosthetic inflammation, and long-term implant survival remains a major challenge in orthopedics. A broad knowledge of the mechanisms underlying the biological response to implant debris would support the development of novel and effective pharmacological strategies to manage PPOL and promote implant lifespan. In this review, a detailed description of the cellular and the molecular mechanisms underlying the biological response to implant debris is provided, highlighting the most recent findings. Furthermore, we reviewed novel therapeutic strategies that are being investigated to prevent inflammatory periprosthetic osteolysis.https://www.frontiersin.org/article/10.3389/fmats.2020.00274/fullorthopedic implantsimplant wear particlesperiprosthetic inflammationosteolysisaseptic loosening |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marina Couto Marina Couto Daniela P. Vasconcelos Daniela P. Vasconcelos Daniela M. Sousa Daniela M. Sousa Beatriz Sousa Beatriz Sousa Beatriz Sousa Francisco Conceição Francisco Conceição Francisco Conceição Estrela Neto Estrela Neto Meriem Lamghari Meriem Lamghari Meriem Lamghari Cecília J. Alves Cecília J. Alves |
spellingShingle |
Marina Couto Marina Couto Daniela P. Vasconcelos Daniela P. Vasconcelos Daniela M. Sousa Daniela M. Sousa Beatriz Sousa Beatriz Sousa Beatriz Sousa Francisco Conceição Francisco Conceição Francisco Conceição Estrela Neto Estrela Neto Meriem Lamghari Meriem Lamghari Meriem Lamghari Cecília J. Alves Cecília J. Alves The Mechanisms Underlying the Biological Response to Wear Debris in Periprosthetic Inflammation Frontiers in Materials orthopedic implants implant wear particles periprosthetic inflammation osteolysis aseptic loosening |
author_facet |
Marina Couto Marina Couto Daniela P. Vasconcelos Daniela P. Vasconcelos Daniela M. Sousa Daniela M. Sousa Beatriz Sousa Beatriz Sousa Beatriz Sousa Francisco Conceição Francisco Conceição Francisco Conceição Estrela Neto Estrela Neto Meriem Lamghari Meriem Lamghari Meriem Lamghari Cecília J. Alves Cecília J. Alves |
author_sort |
Marina Couto |
title |
The Mechanisms Underlying the Biological Response to Wear Debris in Periprosthetic Inflammation |
title_short |
The Mechanisms Underlying the Biological Response to Wear Debris in Periprosthetic Inflammation |
title_full |
The Mechanisms Underlying the Biological Response to Wear Debris in Periprosthetic Inflammation |
title_fullStr |
The Mechanisms Underlying the Biological Response to Wear Debris in Periprosthetic Inflammation |
title_full_unstemmed |
The Mechanisms Underlying the Biological Response to Wear Debris in Periprosthetic Inflammation |
title_sort |
mechanisms underlying the biological response to wear debris in periprosthetic inflammation |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Materials |
issn |
2296-8016 |
publishDate |
2020-08-01 |
description |
Joint replacement surgery is the gold-standard therapeutic approach to treat patients with end-stage hip and knee arthritis, providing pain relief and joint function recovery. Despite the improvements in implant design and surgical techniques, revisions after total joint replacement are expected to grow. The periprosthetic inflammation, featured by the sustained inflammatory response to the implant debris, elicits the activation of osteoclasts and consequent periprosthetic osteolysis (PPOL), ultimately leading to implant aseptic loosening, which is the most common cause of long-term implant failure. There are currently no effective strategies to control periprosthetic inflammation, and long-term implant survival remains a major challenge in orthopedics. A broad knowledge of the mechanisms underlying the biological response to implant debris would support the development of novel and effective pharmacological strategies to manage PPOL and promote implant lifespan. In this review, a detailed description of the cellular and the molecular mechanisms underlying the biological response to implant debris is provided, highlighting the most recent findings. Furthermore, we reviewed novel therapeutic strategies that are being investigated to prevent inflammatory periprosthetic osteolysis. |
topic |
orthopedic implants implant wear particles periprosthetic inflammation osteolysis aseptic loosening |
url |
https://www.frontiersin.org/article/10.3389/fmats.2020.00274/full |
work_keys_str_mv |
AT marinacouto themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT marinacouto themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT danielapvasconcelos themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT danielapvasconcelos themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT danielamsousa themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT danielamsousa themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT beatrizsousa themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT beatrizsousa themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT beatrizsousa themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT franciscoconceicao themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT franciscoconceicao themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT franciscoconceicao themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT estrelaneto themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT estrelaneto themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT meriemlamghari themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT meriemlamghari themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT meriemlamghari themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT ceciliajalves themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT ceciliajalves themechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT marinacouto mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT marinacouto mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT danielapvasconcelos mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT danielapvasconcelos mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT danielamsousa mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT danielamsousa mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT beatrizsousa mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT beatrizsousa mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT beatrizsousa mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT franciscoconceicao mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT franciscoconceicao mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT franciscoconceicao mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT estrelaneto mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT estrelaneto mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT meriemlamghari mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT meriemlamghari mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT meriemlamghari mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT ceciliajalves mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation AT ceciliajalves mechanismsunderlyingthebiologicalresponsetoweardebrisinperiprostheticinflammation |
_version_ |
1724486862646542336 |