Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis
Abstract Background Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. The excess production of pro-inflammatory mediators also impairs insulin...
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doaj-a4037ae426494a16b188880bb0d005db2020-11-24T21:16:54ZengBMCJournal of Inflammation1476-92552018-05-0115111110.1186/s12950-018-0184-9Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsisK. L. C. da Silva0A. P. Camacho1F. C. Mittestainer2B. M. Carvalho3A. Santos4D. Guadagnini5A. G. Oliveira6M. J. A. Saad7Department of Internal Medicine, State University of CampinasDepartment of Internal Medicine, State University of CampinasDepartment of Internal Medicine, State University of CampinasDepartment of Biology Science, Federal University of PernambucoDepartment of Internal Medicine, State University of CampinasDepartment of Internal Medicine, State University of CampinasDepartment of Physical Education, São Paulo State University (UNESP), Bioscience InstituteDepartment of Internal Medicine, State University of CampinasAbstract Background Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. The excess production of pro-inflammatory mediators also impairs insulin signaling, which may be a pathophysiological tissue marker of proinflammatory cytokine action before organ failure. Statins and diacerein have pleiotropic effects, such as the blockage of inflammatory signaling pathways, suggesting that these drugs may be an attractive therapeutic or prophylactic strategy against sepsis. The aim of the present study was to investigate whether a statin or diacerein can improve insulin signaling, disease tolerance and survival in sepsis by inhibiting inflammatory pathways. Methods We investigated the effect of these drugs on survival, tissue insulin signaling and inflammatory pathways in the liver and muscle of rats with sepsis induced by cecal ligation and puncture (CLP). Results The results showed that administration of medications, with anti-inflammatory ability, to septic animals increased survival and improved disease tolerance and insulin resistance in the liver and muscle. The treatment also attenuated ER stress, NF-κB, JNK activation and restored glucose-6-phosphatase (G6Pase) levels in the liver. Conclusions Our results indicate that atorvastatin and diacerein treatment can modulate inflammatory pathways and, in parallel, attenuate insulin resistance in sepsis. Since these two drugs have safety profiles and minimal side effects, we suggest that these drugs may be alternative therapies for the prevention or therapies for the treatment of insulin resistance in sepsis, which could potentially reduce mortality in patients with sepsis.http://link.springer.com/article/10.1186/s12950-018-0184-9StatinDiacereinInsulin resistanceSepsis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
K. L. C. da Silva A. P. Camacho F. C. Mittestainer B. M. Carvalho A. Santos D. Guadagnini A. G. Oliveira M. J. A. Saad |
spellingShingle |
K. L. C. da Silva A. P. Camacho F. C. Mittestainer B. M. Carvalho A. Santos D. Guadagnini A. G. Oliveira M. J. A. Saad Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis Journal of Inflammation Statin Diacerein Insulin resistance Sepsis |
author_facet |
K. L. C. da Silva A. P. Camacho F. C. Mittestainer B. M. Carvalho A. Santos D. Guadagnini A. G. Oliveira M. J. A. Saad |
author_sort |
K. L. C. da Silva |
title |
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis |
title_short |
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis |
title_full |
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis |
title_fullStr |
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis |
title_full_unstemmed |
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis |
title_sort |
atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis |
publisher |
BMC |
series |
Journal of Inflammation |
issn |
1476-9255 |
publishDate |
2018-05-01 |
description |
Abstract Background Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. The excess production of pro-inflammatory mediators also impairs insulin signaling, which may be a pathophysiological tissue marker of proinflammatory cytokine action before organ failure. Statins and diacerein have pleiotropic effects, such as the blockage of inflammatory signaling pathways, suggesting that these drugs may be an attractive therapeutic or prophylactic strategy against sepsis. The aim of the present study was to investigate whether a statin or diacerein can improve insulin signaling, disease tolerance and survival in sepsis by inhibiting inflammatory pathways. Methods We investigated the effect of these drugs on survival, tissue insulin signaling and inflammatory pathways in the liver and muscle of rats with sepsis induced by cecal ligation and puncture (CLP). Results The results showed that administration of medications, with anti-inflammatory ability, to septic animals increased survival and improved disease tolerance and insulin resistance in the liver and muscle. The treatment also attenuated ER stress, NF-κB, JNK activation and restored glucose-6-phosphatase (G6Pase) levels in the liver. Conclusions Our results indicate that atorvastatin and diacerein treatment can modulate inflammatory pathways and, in parallel, attenuate insulin resistance in sepsis. Since these two drugs have safety profiles and minimal side effects, we suggest that these drugs may be alternative therapies for the prevention or therapies for the treatment of insulin resistance in sepsis, which could potentially reduce mortality in patients with sepsis. |
topic |
Statin Diacerein Insulin resistance Sepsis |
url |
http://link.springer.com/article/10.1186/s12950-018-0184-9 |
work_keys_str_mv |
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