Co-infection restrains Litomosoides sigmodontis filarial load and plasmodial P. yoelii but not P. chabaudi parasitaemia in mice
Infection with multiple parasite species is clearly the norm rather than the exception, in animals as well as in humans. Filarial nematodes and Plasmodium spp. are important parasites in human public health and they are often co-endemic. Interactions between these parasites are complex. The mechanis...
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doaj-a4054a24e4db49b7b64be5937434eb3e2021-02-02T03:53:37ZengEDP SciencesParasite1776-10422014-01-01211610.1051/parasite/2014017parasite130079Co-infection restrains Litomosoides sigmodontis filarial load and plasmodial P. yoelii but not P. chabaudi parasitaemia in miceKaradjian GregoryBerrebi DominiqueDogna NathalieVallarino-Lhermitte NathalyBain OdileLandau IrèneMartin CoralieInfection with multiple parasite species is clearly the norm rather than the exception, in animals as well as in humans. Filarial nematodes and Plasmodium spp. are important parasites in human public health and they are often co-endemic. Interactions between these parasites are complex. The mechanisms underlying the modulation of both the course of malaria and the outcome of filarial infection are poorly understood. Despite increasing activity in recent years, studies comparing co- and mono-infections are very much in their infancy and results are contradictory at first sight. In this study we performed controlled and simultaneous co-infections of BALB/c mice with Litomosoides sigmodontis filaria and with Plasmodium spp. (Plasmodium yoelii 17 XNL or Plasmodium chabaudi 864VD). An analysis of pathological lesions in the kidneys and lungs and a parasitological study were conducted at different times of infection. Whatever the plasmodial species, the filarial recovery rate was strongly decreased. The peak of parasitaemia in the plasmodial infection was decreased in the course of P. yoelii infection but not in that of P. chabaudi. Regarding pathological lesions, L. sigmodontis can reverse lesions in the kidneys due to the presence of both Plasmodium species but does not modify the course of pulmonary lesions. The filarial infection induces granulomas in the lungs.http://dx.doi.org/10.1051/parasite/2014017CoinfectionMurineLitomosoides sigmodontisPlasmodiumParasitologyAnatomopathology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karadjian Gregory Berrebi Dominique Dogna Nathalie Vallarino-Lhermitte Nathaly Bain Odile Landau Irène Martin Coralie |
spellingShingle |
Karadjian Gregory Berrebi Dominique Dogna Nathalie Vallarino-Lhermitte Nathaly Bain Odile Landau Irène Martin Coralie Co-infection restrains Litomosoides sigmodontis filarial load and plasmodial P. yoelii but not P. chabaudi parasitaemia in mice Parasite Coinfection Murine Litomosoides sigmodontis Plasmodium Parasitology Anatomopathology |
author_facet |
Karadjian Gregory Berrebi Dominique Dogna Nathalie Vallarino-Lhermitte Nathaly Bain Odile Landau Irène Martin Coralie |
author_sort |
Karadjian Gregory |
title |
Co-infection restrains Litomosoides sigmodontis filarial load and plasmodial P. yoelii but not P. chabaudi parasitaemia in mice |
title_short |
Co-infection restrains Litomosoides sigmodontis filarial load and plasmodial P. yoelii but not P. chabaudi parasitaemia in mice |
title_full |
Co-infection restrains Litomosoides sigmodontis filarial load and plasmodial P. yoelii but not P. chabaudi parasitaemia in mice |
title_fullStr |
Co-infection restrains Litomosoides sigmodontis filarial load and plasmodial P. yoelii but not P. chabaudi parasitaemia in mice |
title_full_unstemmed |
Co-infection restrains Litomosoides sigmodontis filarial load and plasmodial P. yoelii but not P. chabaudi parasitaemia in mice |
title_sort |
co-infection restrains litomosoides sigmodontis filarial load and plasmodial p. yoelii but not p. chabaudi parasitaemia in mice |
publisher |
EDP Sciences |
series |
Parasite |
issn |
1776-1042 |
publishDate |
2014-01-01 |
description |
Infection with multiple parasite species is clearly the norm rather than the exception, in animals as well as in humans. Filarial nematodes and Plasmodium spp. are important parasites in human public health and they are often co-endemic. Interactions between these parasites are complex. The mechanisms underlying the modulation of both the course of malaria and the outcome of filarial infection are poorly understood. Despite increasing activity in recent years, studies comparing co- and mono-infections are very much in their infancy and results are contradictory at first sight. In this study we performed controlled and simultaneous co-infections of BALB/c mice with Litomosoides sigmodontis filaria and with Plasmodium spp. (Plasmodium yoelii 17 XNL or Plasmodium chabaudi 864VD). An analysis of pathological lesions in the kidneys and lungs and a parasitological study were conducted at different times of infection. Whatever the plasmodial species, the filarial recovery rate was strongly decreased. The peak of parasitaemia in the plasmodial infection was decreased in the course of P. yoelii infection but not in that of P. chabaudi. Regarding pathological lesions, L. sigmodontis can reverse lesions in the kidneys due to the presence of both Plasmodium species but does not modify the course of pulmonary lesions. The filarial infection induces granulomas in the lungs. |
topic |
Coinfection Murine Litomosoides sigmodontis Plasmodium Parasitology Anatomopathology |
url |
http://dx.doi.org/10.1051/parasite/2014017 |
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