Aronia melanocarpa ameliorates gout and hyperuricemia in animal models
Aronia melanocarpa fruit (AM) strongly suppressed ankle swelling in rats with acute gout and reduced the levels of uric acid and xanthine oxidase (XO) in mice with hyperuricemia. AM reduced the inflammatory cell count and increased the ankle joint space, and suppressed the levels of interleukin (IL)...
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Online Access: | http://dx.doi.org/10.1080/09540105.2018.1541967 |
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doaj-a405e6969f564877b7853c8e5d6895282020-11-25T00:47:04ZengTaylor & Francis GroupFood and Agricultural Immunology0954-01051465-34432019-01-01301475910.1080/09540105.2018.15419671541967Aronia melanocarpa ameliorates gout and hyperuricemia in animal modelsZhuqian Wang0Xi Wang1Han Yan2Yan Liu3Lanzhou Li4Shaopeng Li5Xiaofeng Wang6Di Wang7Jilin UniversityJilin UniversityJilin UniversityJilin UniversityJilin UniversityZhuhai College of Jilin University, Jilin UniversityChina–Japan Union Hospital of Jilin University, Jilin UniversityJilin UniversityAronia melanocarpa fruit (AM) strongly suppressed ankle swelling in rats with acute gout and reduced the levels of uric acid and xanthine oxidase (XO) in mice with hyperuricemia. AM reduced the inflammatory cell count and increased the ankle joint space, and suppressed the levels of interleukin (IL)-1β, IL-10, monocyte chemoattractant protein-1 and tumour necrosis factor-α in the serum of the rats with acute gout. In the mice with hyperuricemia, AM significantly reduced the serum levels of uric acid, blood urea nitrogen, and creatinine. 8-day administration of AM resulted in enhancements in the levels of glutathione peroxidase, superoxide dismutase and catalase and a reduction in the level of malondialdehyde in the serum of mice. All data suggested that the potential therapeutic effects of AM on gout are probably due to the regulation of pro- and anti-inflammatory cytokines and the suppression of XO activity via modulation of the oxidative stress status.http://dx.doi.org/10.1080/09540105.2018.1541967aronia melanocarpagouty arthritishyperuricemiainflammatory responseoxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhuqian Wang Xi Wang Han Yan Yan Liu Lanzhou Li Shaopeng Li Xiaofeng Wang Di Wang |
spellingShingle |
Zhuqian Wang Xi Wang Han Yan Yan Liu Lanzhou Li Shaopeng Li Xiaofeng Wang Di Wang Aronia melanocarpa ameliorates gout and hyperuricemia in animal models Food and Agricultural Immunology aronia melanocarpa gouty arthritis hyperuricemia inflammatory response oxidative stress |
author_facet |
Zhuqian Wang Xi Wang Han Yan Yan Liu Lanzhou Li Shaopeng Li Xiaofeng Wang Di Wang |
author_sort |
Zhuqian Wang |
title |
Aronia melanocarpa ameliorates gout and hyperuricemia in animal models |
title_short |
Aronia melanocarpa ameliorates gout and hyperuricemia in animal models |
title_full |
Aronia melanocarpa ameliorates gout and hyperuricemia in animal models |
title_fullStr |
Aronia melanocarpa ameliorates gout and hyperuricemia in animal models |
title_full_unstemmed |
Aronia melanocarpa ameliorates gout and hyperuricemia in animal models |
title_sort |
aronia melanocarpa ameliorates gout and hyperuricemia in animal models |
publisher |
Taylor & Francis Group |
series |
Food and Agricultural Immunology |
issn |
0954-0105 1465-3443 |
publishDate |
2019-01-01 |
description |
Aronia melanocarpa fruit (AM) strongly suppressed ankle swelling in rats with acute gout and reduced the levels of uric acid and xanthine oxidase (XO) in mice with hyperuricemia. AM reduced the inflammatory cell count and increased the ankle joint space, and suppressed the levels of interleukin (IL)-1β, IL-10, monocyte chemoattractant protein-1 and tumour necrosis factor-α in the serum of the rats with acute gout. In the mice with hyperuricemia, AM significantly reduced the serum levels of uric acid, blood urea nitrogen, and creatinine. 8-day administration of AM resulted in enhancements in the levels of glutathione peroxidase, superoxide dismutase and catalase and a reduction in the level of malondialdehyde in the serum of mice. All data suggested that the potential therapeutic effects of AM on gout are probably due to the regulation of pro- and anti-inflammatory cytokines and the suppression of XO activity via modulation of the oxidative stress status. |
topic |
aronia melanocarpa gouty arthritis hyperuricemia inflammatory response oxidative stress |
url |
http://dx.doi.org/10.1080/09540105.2018.1541967 |
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