Delta neutrophil index as an early predictor of acute appendicitis and acute complicated appendicitis in adults
Abstract Background This retrospective study aimed to evaluate the ability of the delta neutrophil index (DNI) to predict histologically normal appendicitis preoperatively and to differentiate between simple and complicated appendicitis. Methods The data from 650 patients were divided into positive...
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doaj-a40fccbb9f134684ad38dc734f92d67b2020-11-25T01:41:48ZengBMCWorld Journal of Emergency Surgery1749-79222017-07-011211610.1186/s13017-017-0140-7Delta neutrophil index as an early predictor of acute appendicitis and acute complicated appendicitis in adultsDong Hyuk Shin0Young Suk Cho1Gyu Chong Cho2Hee Cheol Ahn3Seung Min Park4Seung Wook Lim5Young Taeck Oh6Ji Woong Cho7Sang O. Park8Young Hwan Lee9Department of Emergency Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of MedicineDepartment of Emergency Medicine, School of Medicine, Kangdong Sacred Heart Hospital, Hallym UniversityDepartment of Emergency Medicine, School of Medicine, Kangdong Sacred Heart Hospital, Hallym UniversityDepartment of Emergency Medicine, Sacred Heart Hospital, Hallym University School of MedicineDepartment of Emergency Medicine, Sacred Heart Hospital, Hallym University School of MedicineDepartment of Emergency Medicine, Sacred Heart Hospital, Hallym University School of MedicineDepartment of Emergency Medicine, Sacred Heart Hospital, Hallym University School of MedicineDepartment of Surgery, Kangnam Sacred Heart Hospital, Hallym University Medical Center, Hallym University College of MedicineDepartment of Emergency Medicine, School of Medicine, Konkuk University Konkuk University Medical CenterDepartment of Emergency Medicine, Sacred Heart Hospital, Hallym University School of MedicineAbstract Background This retrospective study aimed to evaluate the ability of the delta neutrophil index (DNI) to predict histologically normal appendicitis preoperatively and to differentiate between simple and complicated appendicitis. Methods The data from 650 patients were divided into positive and negative appendectomy groups (histologically normal appendicitis). The patients in the acute appendicitis group were further sub-divided into simple and complicated appendicitis groups. Results The DNI was significantly higher in the positive group than in the negative appendectomy group (0.4 vs. −0.4, p < 0.001) as well as in the complicated group compared with that in the simple appendicitis group (1.2 vs. 0.3, p < 0.001). The DNI independently predicted a positive appendectomy and an acute complicated appendicitis in multivariate logistic regression analysis [odds ratio (OR) 2.62, 95% confidence interval (CI) (1.11~6.16), p = 0.028 and odds ratio (OR) 4.10, 95% confidence interval (CI) (2.94~5.80), p < 0.001]. The optimum cut-off for a positive appendectomy and acute complicated appendicitis were 0.2 [area under curve (AUC) 0.709] and 0.6 (AUC 0.727). Conclusions We suggest that obtaining a preoperative DNI is a useful parameter to aid in the diagnosis of histologically normal appendicitis and to differentiate between simple and complicated appendicitis.http://link.springer.com/article/10.1186/s13017-017-0140-7AppendicitisComplicated appendicitisDelta neutrophil index |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dong Hyuk Shin Young Suk Cho Gyu Chong Cho Hee Cheol Ahn Seung Min Park Seung Wook Lim Young Taeck Oh Ji Woong Cho Sang O. Park Young Hwan Lee |
spellingShingle |
Dong Hyuk Shin Young Suk Cho Gyu Chong Cho Hee Cheol Ahn Seung Min Park Seung Wook Lim Young Taeck Oh Ji Woong Cho Sang O. Park Young Hwan Lee Delta neutrophil index as an early predictor of acute appendicitis and acute complicated appendicitis in adults World Journal of Emergency Surgery Appendicitis Complicated appendicitis Delta neutrophil index |
author_facet |
Dong Hyuk Shin Young Suk Cho Gyu Chong Cho Hee Cheol Ahn Seung Min Park Seung Wook Lim Young Taeck Oh Ji Woong Cho Sang O. Park Young Hwan Lee |
author_sort |
Dong Hyuk Shin |
title |
Delta neutrophil index as an early predictor of acute appendicitis and acute complicated appendicitis in adults |
title_short |
Delta neutrophil index as an early predictor of acute appendicitis and acute complicated appendicitis in adults |
title_full |
Delta neutrophil index as an early predictor of acute appendicitis and acute complicated appendicitis in adults |
title_fullStr |
Delta neutrophil index as an early predictor of acute appendicitis and acute complicated appendicitis in adults |
title_full_unstemmed |
Delta neutrophil index as an early predictor of acute appendicitis and acute complicated appendicitis in adults |
title_sort |
delta neutrophil index as an early predictor of acute appendicitis and acute complicated appendicitis in adults |
publisher |
BMC |
series |
World Journal of Emergency Surgery |
issn |
1749-7922 |
publishDate |
2017-07-01 |
description |
Abstract Background This retrospective study aimed to evaluate the ability of the delta neutrophil index (DNI) to predict histologically normal appendicitis preoperatively and to differentiate between simple and complicated appendicitis. Methods The data from 650 patients were divided into positive and negative appendectomy groups (histologically normal appendicitis). The patients in the acute appendicitis group were further sub-divided into simple and complicated appendicitis groups. Results The DNI was significantly higher in the positive group than in the negative appendectomy group (0.4 vs. −0.4, p < 0.001) as well as in the complicated group compared with that in the simple appendicitis group (1.2 vs. 0.3, p < 0.001). The DNI independently predicted a positive appendectomy and an acute complicated appendicitis in multivariate logistic regression analysis [odds ratio (OR) 2.62, 95% confidence interval (CI) (1.11~6.16), p = 0.028 and odds ratio (OR) 4.10, 95% confidence interval (CI) (2.94~5.80), p < 0.001]. The optimum cut-off for a positive appendectomy and acute complicated appendicitis were 0.2 [area under curve (AUC) 0.709] and 0.6 (AUC 0.727). Conclusions We suggest that obtaining a preoperative DNI is a useful parameter to aid in the diagnosis of histologically normal appendicitis and to differentiate between simple and complicated appendicitis. |
topic |
Appendicitis Complicated appendicitis Delta neutrophil index |
url |
http://link.springer.com/article/10.1186/s13017-017-0140-7 |
work_keys_str_mv |
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