LAL test and RPT for endotoxin detection of CPT-11/DSPE-mPEG2000 nanoformulation: What if traditional methods are not applicable?

LAL test and RPT for endotoxin detection of CPT-11/DSPE-mPEG2000 nanoformulation: What if traditional methods are not applicable?

Endotoxin detection is an important step in drug characterization. Herein we found that a chemotherapeutic drug nanoformulation composed of irinotecan hydrochloride (CPT-11) and an amphiphilic molecule DSPE-mPEG2000 can interfere with the limulus amebocyte lysate assay (LAL). Furthermore, the rabbit...

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Bibliographic Details
Main Authors: Yanan Jin, Juanjuan Jia, Chan Li, Jianqi Xue, Jiabei Sun, Kaiyuan Wang, Yaling Gan, Jing Xu, Yaqin Shi, Xingjie Liang
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Asian Journal of Pharmaceutical Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087617307286

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