The effect of the aluminum chloride – quercetin complex on Ca(2+),Mg(2+)-ATPase activity and contraction dynamic properties of muscle tibialis anterior from Rana temporaria
Combined effect of aluminum chloride and quercetin solutions on the enzymatic activity and contraction dynamics of muscle fiber bundles of the Rana temporaria m. tibialis anterior was investigated. It was shown that these complexes inhibit muscle contraction. Linear reduction of Ca2+,Mg2+-ATPase act...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.
2015-12-01
|
Series: | Ukrainian Biochemical Journal |
Subjects: | |
Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2015/12/Nozdrenko_6_15.pdf |
id |
doaj-a4211296788f4b0588703d3745a006a6 |
---|---|
record_format |
Article |
spelling |
doaj-a4211296788f4b0588703d3745a006a62020-11-24T21:02:19ZengNational Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.Ukrainian Biochemical Journal2409-49432413-50032015-12-01876768510.15407/ubj87.06.076The effect of the aluminum chloride – quercetin complex on Ca(2+),Mg(2+)-ATPase activity and contraction dynamic properties of muscle tibialis anterior from Rana temporariaD. M. Nozdrenko0O. M. Аbramchuk1 V. M. Soroca2N. S. Miroshnichenko3Educational and Scientific Centre “Institute of Biology”,Taras Shevchenko National University of Kyiv, Ukraine;Lesya Ukrainka Eastern European National University, Lutsk, UkraineEducational and Scientific Centre “Institute of Biology”,Taras Shevchenko National University of Kyiv, Ukraine;Educational and Scientific Centre “Institute of Biology”,Taras Shevchenko National University of Kyiv, Ukraine;Combined effect of aluminum chloride and quercetin solutions on the enzymatic activity and contraction dynamics of muscle fiber bundles of the Rana temporaria m. tibialis anterior was investigated. It was shown that these complexes inhibit muscle contraction. Linear reduction of Ca2+,Mg2+-ATPase activity induced by all of the used concentrations of AlCl3 – quercetin was demonstrated. It was found that complex of quercetin with AlCl3 has a greater inhibitory effect on muscle contraction dynamic and causes greater reduction during all periods of stimulation in comparison to the separate effect of the investigated compounds. All the studied concentrations of AlCl3 and quercetin solutions (AlCl3: 10-4-10-2 M; quercetin: 10-6-10-5 M) caused concentration depended contraction strengths and lengths reduction. The decrease in strength and length of muscle contractions was of constant and mostly linear nature within observed timeframe as well as within each periods of contraction. The changes were least pronounced within pretetanic period, but were profound within terminal period of muscle activity. The changes in dynamic contraction properties and Ca2+,Mg2+-ATPase activity of sarcoplasmic reticulum under effect of the investigated compounds was minimal in the beginning of the muscle’s response to stimulus, prior to muscle strength reaching stable contraction level.http://ukrbiochemjournal.org/wp-content/uploads/2015/12/Nozdrenko_6_15.pdfaluminumCa(2+)-Mg(2+)-ATPase activitylengthmuscle contractionstrength |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
D. M. Nozdrenko O. M. Аbramchuk V. M. Soroca N. S. Miroshnichenko |
spellingShingle |
D. M. Nozdrenko O. M. Аbramchuk V. M. Soroca N. S. Miroshnichenko The effect of the aluminum chloride – quercetin complex on Ca(2+),Mg(2+)-ATPase activity and contraction dynamic properties of muscle tibialis anterior from Rana temporaria Ukrainian Biochemical Journal aluminum Ca(2+)-Mg(2+)-ATPase activity length muscle contraction strength |
author_facet |
D. M. Nozdrenko O. M. Аbramchuk V. M. Soroca N. S. Miroshnichenko |
author_sort |
D. M. Nozdrenko |
title |
The effect of the aluminum chloride – quercetin complex on Ca(2+),Mg(2+)-ATPase activity and contraction dynamic properties of muscle tibialis anterior from Rana temporaria |
title_short |
The effect of the aluminum chloride – quercetin complex on Ca(2+),Mg(2+)-ATPase activity and contraction dynamic properties of muscle tibialis anterior from Rana temporaria |
title_full |
The effect of the aluminum chloride – quercetin complex on Ca(2+),Mg(2+)-ATPase activity and contraction dynamic properties of muscle tibialis anterior from Rana temporaria |
title_fullStr |
The effect of the aluminum chloride – quercetin complex on Ca(2+),Mg(2+)-ATPase activity and contraction dynamic properties of muscle tibialis anterior from Rana temporaria |
title_full_unstemmed |
The effect of the aluminum chloride – quercetin complex on Ca(2+),Mg(2+)-ATPase activity and contraction dynamic properties of muscle tibialis anterior from Rana temporaria |
title_sort |
effect of the aluminum chloride – quercetin complex on ca(2+),mg(2+)-atpase activity and contraction dynamic properties of muscle tibialis anterior from rana temporaria |
publisher |
National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. |
series |
Ukrainian Biochemical Journal |
issn |
2409-4943 2413-5003 |
publishDate |
2015-12-01 |
description |
Combined effect of aluminum chloride and quercetin solutions on the enzymatic activity and contraction dynamics of muscle fiber bundles of the Rana temporaria m. tibialis anterior was investigated. It was shown that these complexes inhibit muscle contraction. Linear reduction of Ca2+,Mg2+-ATPase activity induced by all of the used concentrations of AlCl3 – quercetin was demonstrated. It was found that complex of quercetin with AlCl3 has a greater inhibitory effect on muscle contraction dynamic and causes greater reduction during all periods of stimulation in comparison to the separate effect of the investigated compounds. All the studied concentrations of AlCl3 and quercetin solutions (AlCl3: 10-4-10-2 M; quercetin: 10-6-10-5 M) caused concentration depended contraction strengths and lengths reduction. The decrease in strength and length of muscle contractions was of constant and mostly linear nature within observed timeframe as well as within each periods of contraction. The changes were least pronounced within pretetanic period, but were profound within terminal period of muscle activity. The changes in dynamic contraction properties and Ca2+,Mg2+-ATPase activity of sarcoplasmic reticulum under effect of the investigated compounds was minimal in the beginning of the muscle’s response to stimulus, prior to muscle strength reaching stable contraction level. |
topic |
aluminum Ca(2+)-Mg(2+)-ATPase activity length muscle contraction strength |
url |
http://ukrbiochemjournal.org/wp-content/uploads/2015/12/Nozdrenko_6_15.pdf |
work_keys_str_mv |
AT dmnozdrenko theeffectofthealuminumchloridequercetincomplexonca2mg2atpaseactivityandcontractiondynamicpropertiesofmuscletibialisanteriorfromranatemporaria AT omabramchuk theeffectofthealuminumchloridequercetincomplexonca2mg2atpaseactivityandcontractiondynamicpropertiesofmuscletibialisanteriorfromranatemporaria AT vmsoroca theeffectofthealuminumchloridequercetincomplexonca2mg2atpaseactivityandcontractiondynamicpropertiesofmuscletibialisanteriorfromranatemporaria AT nsmiroshnichenko theeffectofthealuminumchloridequercetincomplexonca2mg2atpaseactivityandcontractiondynamicpropertiesofmuscletibialisanteriorfromranatemporaria AT dmnozdrenko effectofthealuminumchloridequercetincomplexonca2mg2atpaseactivityandcontractiondynamicpropertiesofmuscletibialisanteriorfromranatemporaria AT omabramchuk effectofthealuminumchloridequercetincomplexonca2mg2atpaseactivityandcontractiondynamicpropertiesofmuscletibialisanteriorfromranatemporaria AT vmsoroca effectofthealuminumchloridequercetincomplexonca2mg2atpaseactivityandcontractiondynamicpropertiesofmuscletibialisanteriorfromranatemporaria AT nsmiroshnichenko effectofthealuminumchloridequercetincomplexonca2mg2atpaseactivityandcontractiondynamicpropertiesofmuscletibialisanteriorfromranatemporaria |
_version_ |
1716775799026089984 |