Myeloid Ezh2 Deficiency Limits Atherosclerosis Development

Myeloid Ezh2 Deficiency Limits Atherosclerosis Development

Macrophages define a key component of immune cells present in atherosclerotic lesions and are central regulators of the disease. Since epigenetic processes are important in controlling macrophage function, interfering with epigenetic pathways in macrophages might be a novel approach to combat athero...

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Bibliographic Details
Main Authors: Annette E. Neele, Hung-Jen Chen, Marion J. J. Gijbels, Saskia van der Velden, Marten A. Hoeksema, Marieke C. S. Boshuizen, Jan Van den Bossche, Anton T. Tool, Hanke L. Matlung, Timo K. van den Berg, Esther Lutgens, Menno P. J. de Winther
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
atherosclerosis
epigenetic
histone modification
H3K27
macrophage
polycomb
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.594603/full

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