Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease Virus

Foot-and-mouth disease virus (FMDV) causes a highly contagious vesicular disease in cloven-hoofed livestock that results in severe consequences for international trade, posing a great economic threat to agriculture. The FMDV infection antagonizes the host immune responses via different signaling pat...

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Main Authors:	Bo Yang, Xiaohui Zhang, Dajun Zhang, Jing Hou, GuoWei Xu, Chaochao Sheng, Sk Mohiuddin Choudhury, Zixiang Zhu, Dan Li, Keshan Zhang, Haixue Zheng, Xiangtao Liu
Format:	Article
Language:	English
Published:	MDPI AG 2020-09-01
Series:	Pathogens
Subjects:	foot-and-mouth disease virus immune escape innate immune response interferon protein interaction viral protein
Online Access:	https://www.mdpi.com/2076-0817/9/9/729

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spelling	doaj-a42e854a5fc446658b95d605f63779582020-11-25T03:20:45ZengMDPI AGPathogens2076-08172020-09-01972972910.3390/pathogens9090729Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease VirusBo Yang0Xiaohui Zhang1Dajun Zhang2Jing Hou3GuoWei Xu4Chaochao Sheng5Sk Mohiuddin Choudhury6Zixiang Zhu7Dan Li8Keshan Zhang9Haixue Zheng10Xiangtao Liu11State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou 730046, ChinaState Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou 730046, ChinaState Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou 730046, ChinaState Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou 730046, ChinaState Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou 730046, ChinaState Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou 730046, ChinaState Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou 730046, ChinaState Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou 730046, ChinaState Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou 730046, ChinaState Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou 730046, ChinaState Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou 730046, ChinaState Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou 730046, ChinaFoot-and-mouth disease virus (FMDV) causes a highly contagious vesicular disease in cloven-hoofed livestock that results in severe consequences for international trade, posing a great economic threat to agriculture. The FMDV infection antagonizes the host immune responses via different signaling pathways to achieve immune escape. Strategies to escape the cell immune system are key to effective infection and pathogenesis. This review is focused on summarizing the recent advances to understand how the proteins encoded by FMDV antagonize the host innate and adaptive immune responses.https://www.mdpi.com/2076-0817/9/9/729foot-and-mouth disease virusimmune escapeinnate immune responseinterferonprotein interactionviral protein
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Bo Yang Xiaohui Zhang Dajun Zhang Jing Hou GuoWei Xu Chaochao Sheng Sk Mohiuddin Choudhury Zixiang Zhu Dan Li Keshan Zhang Haixue Zheng Xiangtao Liu
spellingShingle	Bo Yang Xiaohui Zhang Dajun Zhang Jing Hou GuoWei Xu Chaochao Sheng Sk Mohiuddin Choudhury Zixiang Zhu Dan Li Keshan Zhang Haixue Zheng Xiangtao Liu Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease Virus Pathogens foot-and-mouth disease virus immune escape innate immune response interferon protein interaction viral protein
author_facet	Bo Yang Xiaohui Zhang Dajun Zhang Jing Hou GuoWei Xu Chaochao Sheng Sk Mohiuddin Choudhury Zixiang Zhu Dan Li Keshan Zhang Haixue Zheng Xiangtao Liu
author_sort	Bo Yang
title	Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease Virus
title_short	Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease Virus
title_full	Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease Virus
title_fullStr	Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease Virus
title_full_unstemmed	Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease Virus
title_sort	molecular mechanisms of immune escape for foot-and-mouth disease virus
publisher	MDPI AG
series	Pathogens
issn	2076-0817
publishDate	2020-09-01
description	Foot-and-mouth disease virus (FMDV) causes a highly contagious vesicular disease in cloven-hoofed livestock that results in severe consequences for international trade, posing a great economic threat to agriculture. The FMDV infection antagonizes the host immune responses via different signaling pathways to achieve immune escape. Strategies to escape the cell immune system are key to effective infection and pathogenesis. This review is focused on summarizing the recent advances to understand how the proteins encoded by FMDV antagonize the host innate and adaptive immune responses.
topic	foot-and-mouth disease virus immune escape innate immune response interferon protein interaction viral protein
url	https://www.mdpi.com/2076-0817/9/9/729
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Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease Virus

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