Genetic Associations Between IL-6 and the Development of Autoimmune Arthritis Are Gender-Specific

Genetic Associations Between IL-6 and the Development of Autoimmune Arthritis Are Gender-Specific

ObjectivesTo find out the genetic association between IL6 and autoimmune arthritis.MethodsWe performed a two-sample Mendelian randomization (MR) study using multiple genome-wide association studies (GWAS) datasets. Furthermore, a sex-stratified MR study was performed to identify sexual dimorphism in...

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Bibliographic Details
Main Authors: Jianqiao Hong, Zihao Qu, Xiaoxiao Ji, Congsun Li, Geng Zhang, Ciliang Jin, Jie Wang, Yongxing Zhang, Yue Shen, Jiahong Meng, Chenhe Zhou, Chaohua Fang, Wei Wang, Shigui Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
Mendelian randomization
IL6
sIL6R
autoimmune arthritis
ADAR
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.707617/full

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