Serum E-selectin concentration is associated with risk of metabolic syndrome in females.
OBJECTIVES:Traits of metabolic syndrome (MetS) and biomarkers of inflammation and endothelial dysfunction were examined. We investigated the differences of various biomarkers among individuals with or without Mets in a gender-specific manner. The gender-specific associations between E-selectin and M...
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doaj-a43ac8dfb70f4df1b29868f0d023f14c2021-03-03T21:21:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01149e022281510.1371/journal.pone.0222815Serum E-selectin concentration is associated with risk of metabolic syndrome in females.Chien-Hsing LeeFeng-Chih KuoWen-Hao TangChieh-Hua LuSheng-Chiang SuJhih-Syuan LiuChang-Hsun HsiehYi-Jen HungFu-Huang LinOBJECTIVES:Traits of metabolic syndrome (MetS) and biomarkers of inflammation and endothelial dysfunction were examined. We investigated the differences of various biomarkers among individuals with or without Mets in a gender-specific manner. The gender-specific associations between E-selectin and MetS were further evaluated. METHODS:A total of 205 patients were recruited from the outpatient clinics of Tri-Service General Hospital, Taipei, Taiwan. Inclusion criteria were age between 20-75 years and BMI < 35 kg/m2. Demographic, anthropometric and MetS index data were compared between genders. Markers of inflammation and endothelial dysfunction were compared between individuals with or without MetS by gender. RESULTS:Age-adjusted E-selectin values showed significant positive correlations with BMI, waist-hip ratio, fasting plasma glucose, systolic and diastolic blood pressure, triglycerides, TNF-α, hsCRP and ICAM-1, and inverse correlation with HDL cholesterol. E-selectin levels were positively correlated with numbers of MetS components in females (P < 0.001) but not in males (P = 0.125). CONCLUSIONS:Increased E-selectin levels are significantly associated with increased MetS risk in females, but not in males.https://doi.org/10.1371/journal.pone.0222815 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chien-Hsing Lee Feng-Chih Kuo Wen-Hao Tang Chieh-Hua Lu Sheng-Chiang Su Jhih-Syuan Liu Chang-Hsun Hsieh Yi-Jen Hung Fu-Huang Lin |
spellingShingle |
Chien-Hsing Lee Feng-Chih Kuo Wen-Hao Tang Chieh-Hua Lu Sheng-Chiang Su Jhih-Syuan Liu Chang-Hsun Hsieh Yi-Jen Hung Fu-Huang Lin Serum E-selectin concentration is associated with risk of metabolic syndrome in females. PLoS ONE |
author_facet |
Chien-Hsing Lee Feng-Chih Kuo Wen-Hao Tang Chieh-Hua Lu Sheng-Chiang Su Jhih-Syuan Liu Chang-Hsun Hsieh Yi-Jen Hung Fu-Huang Lin |
author_sort |
Chien-Hsing Lee |
title |
Serum E-selectin concentration is associated with risk of metabolic syndrome in females. |
title_short |
Serum E-selectin concentration is associated with risk of metabolic syndrome in females. |
title_full |
Serum E-selectin concentration is associated with risk of metabolic syndrome in females. |
title_fullStr |
Serum E-selectin concentration is associated with risk of metabolic syndrome in females. |
title_full_unstemmed |
Serum E-selectin concentration is associated with risk of metabolic syndrome in females. |
title_sort |
serum e-selectin concentration is associated with risk of metabolic syndrome in females. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2019-01-01 |
description |
OBJECTIVES:Traits of metabolic syndrome (MetS) and biomarkers of inflammation and endothelial dysfunction were examined. We investigated the differences of various biomarkers among individuals with or without Mets in a gender-specific manner. The gender-specific associations between E-selectin and MetS were further evaluated. METHODS:A total of 205 patients were recruited from the outpatient clinics of Tri-Service General Hospital, Taipei, Taiwan. Inclusion criteria were age between 20-75 years and BMI < 35 kg/m2. Demographic, anthropometric and MetS index data were compared between genders. Markers of inflammation and endothelial dysfunction were compared between individuals with or without MetS by gender. RESULTS:Age-adjusted E-selectin values showed significant positive correlations with BMI, waist-hip ratio, fasting plasma glucose, systolic and diastolic blood pressure, triglycerides, TNF-α, hsCRP and ICAM-1, and inverse correlation with HDL cholesterol. E-selectin levels were positively correlated with numbers of MetS components in females (P < 0.001) but not in males (P = 0.125). CONCLUSIONS:Increased E-selectin levels are significantly associated with increased MetS risk in females, but not in males. |
url |
https://doi.org/10.1371/journal.pone.0222815 |
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