Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases
Mesenchymal stem cells (MSCs) are the most exploited stem cells with multilineage differentiation potential and immunomodulatory properties. Numerous lines of findings have reported their successful applications in a multitude of inflammatory conditions and immune disorders. However, it is currently...
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Hindawi Limited
2021-01-01
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Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2021/4539453 |
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doaj-a4455d0a518f4fca9526ea6a8d2b4c4d2021-10-11T00:39:38ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09942021-01-01202110.1155/2021/4539453Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological DiseasesMin Shen0Tong Chen1Department of HematologyDepartment of HematologyMesenchymal stem cells (MSCs) are the most exploited stem cells with multilineage differentiation potential and immunomodulatory properties. Numerous lines of findings have reported their successful applications in a multitude of inflammatory conditions and immune disorders. However, it is currently discovered that these effects are mainly mediated in a paracrine manner by MSC-exosomes. Moreover, MSC-exosomes have been implicated in a wide variety of biological responses including immunomodulation, oxidative stress, tumor progression, and tissue regeneration. Meanwhile, they are reported to actively participate in various hematological diseases by the means of transferring different types of exosomal components to the target cells. Therefore, in this review, we briefly discuss the sources and biological features of MSCs and then illustrate the biogenesis and biological processes of MSC-exosomes. Of note, this paper especially highlights the latest research progress of MSC-exosomes in hematological diseases.http://dx.doi.org/10.1155/2021/4539453 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Min Shen Tong Chen |
spellingShingle |
Min Shen Tong Chen Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases Oxidative Medicine and Cellular Longevity |
author_facet |
Min Shen Tong Chen |
author_sort |
Min Shen |
title |
Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases |
title_short |
Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases |
title_full |
Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases |
title_fullStr |
Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases |
title_full_unstemmed |
Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases |
title_sort |
mesenchymal stem cell-derived exosomes and their potential agents in hematological diseases |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0994 |
publishDate |
2021-01-01 |
description |
Mesenchymal stem cells (MSCs) are the most exploited stem cells with multilineage differentiation potential and immunomodulatory properties. Numerous lines of findings have reported their successful applications in a multitude of inflammatory conditions and immune disorders. However, it is currently discovered that these effects are mainly mediated in a paracrine manner by MSC-exosomes. Moreover, MSC-exosomes have been implicated in a wide variety of biological responses including immunomodulation, oxidative stress, tumor progression, and tissue regeneration. Meanwhile, they are reported to actively participate in various hematological diseases by the means of transferring different types of exosomal components to the target cells. Therefore, in this review, we briefly discuss the sources and biological features of MSCs and then illustrate the biogenesis and biological processes of MSC-exosomes. Of note, this paper especially highlights the latest research progress of MSC-exosomes in hematological diseases. |
url |
http://dx.doi.org/10.1155/2021/4539453 |
work_keys_str_mv |
AT minshen mesenchymalstemcellderivedexosomesandtheirpotentialagentsinhematologicaldiseases AT tongchen mesenchymalstemcellderivedexosomesandtheirpotentialagentsinhematologicaldiseases |
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1716829134173241344 |