Comparison of changes in serum fibrinogen level in primary intracranial hemorrhage (ICH) and ischemic stroke

• Main Authors: Ahmad Chitsaz, Sayed Ali Mousavi, Yamen Yousef, Vahab Mostafa
• Format: Article
• Language: English
• Published: Vesnu Publications 2011-12-01
• Series: ARYA Atherosclerosis
• Online Access: http://arya.mui.ac.ir/index.php/arya/article/view/331

associated with increased risk of stroke. This study aimed to determine the type of stroke and<br />the role of fibrinogen in stroke type.<br />METHODS: This case-control study comprised 58 hospitalized patients with intracranial<br />hemorrhage (ICH) and ischemic stroke. Demographic and clinical characteristics, type of stroke<br />and fibrinogen level were collected after starting the treatment.<br />RESULTS: The prevalence of ICH was higher in men than in women so that 60% of men and<br />39.3% of women in this study were diagnosed with this type of stroke. In contrast, the<br />corresponding figures for ischemic stroke were 40% and 60.7%, respectively. Statistical analysis<br />by chi-square test revealed significant difference in the type of stoke in terms of gender<br />(P = 0.026). The mean fibrinogen levels was lower in patients with ICH (348 &plusmn; 96 mg/dl) than<br />in patients with ischemic stroke (381 &plusmn; 126 mg/dl), however this difference was not statistically<br />significant (P = 0.12). Fibrinogen levels were significantly higher in women than in men<br />(390 &plusmn; 111 vs. 340 &plusmn; 110 mg/dl, respectively, P = 0.017).<br />CONCLUSION: Although the mean fibrinogen level was not significantly different in ICH and<br />ischemic stroke patients, it is recommended to examine the serum fibrinogen and its related<br />factors at least for those patients with non-modifiable risk factors and in particular for those<br />with family history and genetic background.<br />Keywords: Cardiovascular Diseases; Ischemic Stroke; Fibrinogen.