Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells

Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells

Abstract Background Targeting epigenetic modifiers is effective in cutaneous T cell lymphoma (CTCL). However, there is a need for further improvement of this therapeutic approach. Here, we compared the mode of action of romidepsin (FK228), an established class I histone deacetylase inhibitor, and do...

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Main Authors: Marion Wobser, Alexandra Weber, Amelie Glunz, Saskia Tauch, Kristina Seitz, Tobias Butelmann, Sonja Hesbacher, Matthias Goebeler, René Bartz, Hella Kohlhof, David Schrama, Roland Houben
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Hematology & Oncology
Subjects:
Cutaneous lymphoma
Epigenetic regulation
Histone deacetylase
HDAC
Lysine-specific methylase
LSD1
Online Access:http://link.springer.com/article/10.1186/s13045-019-0719-4

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