Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases
The emerging concept of microbiota contributing to local mucosal homeostasis has fueled investigation into its specific role in immunology. Gut microbiota is mostly responsible for maintaining the balance between host defense and immune tolerance. Dysbiosis of gut microbiota has been shown to be rel...
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doaj-a44b40e60ec044c0a1588a2b9054b8012020-11-25T02:05:11ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-02-011110.3389/fimmu.2020.00282503395Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune DiseasesYuhao Jiao0Yuhao Jiao1Li Wu2Li Wu3Li Wu4Nicholas D. Huntington5Xuan Zhang6Xuan Zhang7The Ministry of Education Key Laboratory, Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaSchool of Medicine, Tsinghua University, Beijing, ChinaInstitute for Immunology, Tsinghua University, Beijing, ChinaTsinghua-Peking Joint Centre for Life Sciences, Beijing, ChinaBeijing Key Laboratory for Immunological Research on Chronic Diseases, Beijing, ChinaDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, AustraliaThe Ministry of Education Key Laboratory, Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaClinical Immunology Centre, Medical Epigenetics Research Centre, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaThe emerging concept of microbiota contributing to local mucosal homeostasis has fueled investigation into its specific role in immunology. Gut microbiota is mostly responsible for maintaining the balance between host defense and immune tolerance. Dysbiosis of gut microbiota has been shown to be related to various alterations of the immune system. This review focuses on the reciprocal relationship between gut microbiota and innate immunity compartment, with emphasis on gut-associated lymphoid tissue, innate lymphoid cells, and phagocytes. From a clinical perspective, the review gives a possible explanation of how the “gut microbiota—innate immunity” axis might contribute to the pathogenesis of autoimmune diseases like rheumatoid arthritis, spondyloarthritis, and systemic lupus erythematosus.https://www.frontiersin.org/article/10.3389/fimmu.2020.00282/fullgut microbiotainnate immunityinnate lymphoid cellsrheumatoid arthritisspondyloarthritissystemic lupus erythematosus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuhao Jiao Yuhao Jiao Li Wu Li Wu Li Wu Nicholas D. Huntington Xuan Zhang Xuan Zhang |
spellingShingle |
Yuhao Jiao Yuhao Jiao Li Wu Li Wu Li Wu Nicholas D. Huntington Xuan Zhang Xuan Zhang Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases Frontiers in Immunology gut microbiota innate immunity innate lymphoid cells rheumatoid arthritis spondyloarthritis systemic lupus erythematosus |
author_facet |
Yuhao Jiao Yuhao Jiao Li Wu Li Wu Li Wu Nicholas D. Huntington Xuan Zhang Xuan Zhang |
author_sort |
Yuhao Jiao |
title |
Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases |
title_short |
Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases |
title_full |
Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases |
title_fullStr |
Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases |
title_full_unstemmed |
Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases |
title_sort |
crosstalk between gut microbiota and innate immunity and its implication in autoimmune diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-02-01 |
description |
The emerging concept of microbiota contributing to local mucosal homeostasis has fueled investigation into its specific role in immunology. Gut microbiota is mostly responsible for maintaining the balance between host defense and immune tolerance. Dysbiosis of gut microbiota has been shown to be related to various alterations of the immune system. This review focuses on the reciprocal relationship between gut microbiota and innate immunity compartment, with emphasis on gut-associated lymphoid tissue, innate lymphoid cells, and phagocytes. From a clinical perspective, the review gives a possible explanation of how the “gut microbiota—innate immunity” axis might contribute to the pathogenesis of autoimmune diseases like rheumatoid arthritis, spondyloarthritis, and systemic lupus erythematosus. |
topic |
gut microbiota innate immunity innate lymphoid cells rheumatoid arthritis spondyloarthritis systemic lupus erythematosus |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.00282/full |
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