Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor

Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor

Activating mutations in fibroblast growth factor (FGF) receptor 3 and inactivating mutations in the NPR2 guanylyl cyclase both cause severe short stature, but how these two signaling systems interact to regulate bone growth is poorly understood. Here, we show that bone elongation is increased when N...

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Bibliographic Details
Main Authors: Leia C Shuhaibar, Jerid W Robinson, Giulia Vigone, Ninna P Shuhaibar, Jeremy R Egbert, Valentina Baena, Tracy F Uliasz, Deborah Kaback, Siu-Pok Yee, Robert Feil, Melanie C Fisher, Caroline N Dealy, Lincoln R Potter, Laurinda A Jaffe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
growth plate
chondrocyte
NPR2 guanylyl cyclase
dephosphorylation
cyclic GMP
fibroblast growth factor
Online Access:https://elifesciences.org/articles/31343

Internet

https://elifesciences.org/articles/31343

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