Evasion of the Host Immune Response by Betaherpesviruses
The human immune system boasts a diverse array of strategies for recognizing and eradicating invading pathogens. Human betaherpesviruses, a highly prevalent subfamily of viruses, include human cytomegalovirus (HCMV), human herpesvirus (HHV) 6A, HHV-6B, and HHV-7. These viruses have evolved numerous...
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doaj-a450cd5169744713a771cbfa7960c2732021-07-23T13:46:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-01227503750310.3390/ijms22147503Evasion of the Host Immune Response by BetaherpesvirusesDaniel G. Sausen0Kirstin M. Reed1Maimoona S. Bhutta2Elisa S. Gallo3Ronen Borenstein4Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USADepartment of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USADepartment of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USABoard-Certified Dermatologist and Independent Researcher, Norfolk, VA 23507, USADepartment of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USAThe human immune system boasts a diverse array of strategies for recognizing and eradicating invading pathogens. Human betaherpesviruses, a highly prevalent subfamily of viruses, include human cytomegalovirus (HCMV), human herpesvirus (HHV) 6A, HHV-6B, and HHV-7. These viruses have evolved numerous mechanisms for evading the host response. In this review, we will highlight the complex interplay between betaherpesviruses and the human immune response, focusing on protein function. We will explore methods by which the immune system first responds to betaherpesvirus infection as well as mechanisms by which viruses subvert normal cellular functions to evade the immune system and facilitate viral latency, persistence, and reactivation. Lastly, we will briefly discuss recent advances in vaccine technology targeting betaherpesviruses. This review aims to further elucidate the dynamic interactions between betaherpesviruses and the human immune system.https://www.mdpi.com/1422-0067/22/14/7503betaherpesvirusimmune evasionviral evasionimmune responseHCMVHHV-6A |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniel G. Sausen Kirstin M. Reed Maimoona S. Bhutta Elisa S. Gallo Ronen Borenstein |
spellingShingle |
Daniel G. Sausen Kirstin M. Reed Maimoona S. Bhutta Elisa S. Gallo Ronen Borenstein Evasion of the Host Immune Response by Betaherpesviruses International Journal of Molecular Sciences betaherpesvirus immune evasion viral evasion immune response HCMV HHV-6A |
author_facet |
Daniel G. Sausen Kirstin M. Reed Maimoona S. Bhutta Elisa S. Gallo Ronen Borenstein |
author_sort |
Daniel G. Sausen |
title |
Evasion of the Host Immune Response by Betaherpesviruses |
title_short |
Evasion of the Host Immune Response by Betaherpesviruses |
title_full |
Evasion of the Host Immune Response by Betaherpesviruses |
title_fullStr |
Evasion of the Host Immune Response by Betaherpesviruses |
title_full_unstemmed |
Evasion of the Host Immune Response by Betaherpesviruses |
title_sort |
evasion of the host immune response by betaherpesviruses |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-07-01 |
description |
The human immune system boasts a diverse array of strategies for recognizing and eradicating invading pathogens. Human betaherpesviruses, a highly prevalent subfamily of viruses, include human cytomegalovirus (HCMV), human herpesvirus (HHV) 6A, HHV-6B, and HHV-7. These viruses have evolved numerous mechanisms for evading the host response. In this review, we will highlight the complex interplay between betaherpesviruses and the human immune response, focusing on protein function. We will explore methods by which the immune system first responds to betaherpesvirus infection as well as mechanisms by which viruses subvert normal cellular functions to evade the immune system and facilitate viral latency, persistence, and reactivation. Lastly, we will briefly discuss recent advances in vaccine technology targeting betaherpesviruses. This review aims to further elucidate the dynamic interactions between betaherpesviruses and the human immune system. |
topic |
betaherpesvirus immune evasion viral evasion immune response HCMV HHV-6A |
url |
https://www.mdpi.com/1422-0067/22/14/7503 |
work_keys_str_mv |
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1721287934252941312 |